USE OF POLYOXIDONIUM IN THE TREATMENT OF OBSTRUCTIVE BRONCHITIS IN CHILDREN

Abstract

Obstructive bronchitis is one of the most frequent hospitalizations of young children, which is characterized by manifestations of broncho-obstructive syndrome, respiratory failure. The main causative agent of obstructive bronchitis is a virus. Since the main pathogenetic link is the formation of inflammation of the bronchi, we treated with the use of an immunostimulating drug - Polyoxidonium. We have treated 64 patients aged 6 to 5 years who were divided into 2 groups. Patients received inpatient treatment at the Samarkand Branch of the Republican Scientific Center for Emergency Medical Care, in departments 1 and 2 of pediatrics. Group 2 was prescribed Polyoxidonium, which was administered intramuscularly at a dose of 0.1 mg/kg, 1 time every other day. According to the results of the study, it was noted that patients receiving Polyoxidonium had significantly accelerated elimination of cyanosis (by 0.7 days; P<0.05), cough relief (by 0.9 days; P<0.05), disappearance of respiratory failure (by 0.7 days; P<0.05), the disappearance of shortness of breath (by 1.4 days; P<0.001) in comparison with the control group. Thus, the use of polyoxidonium led to a decrease in the duration of hospitalization by an average of 1.1 bed-days (P<0.01) compared with standard therapy.