SURUNKALI OBSTRUKTIV BRONXIT MUHITIDA ATOPIK DERMATITLI BOLALAR TERISINING MORFOLOGIK XUSUSIYATLARI
Abstrakt
Dolzarbligi. Atopik dermatit (AD) bolalikning eng keng tarqalgan atopik kasalliklaridan biri bo'lib, erta boshlanishi, klinik ko'rinishlarning polimorfizmi va turli patomorfologik xususiyatlar, shuningdek, bemorning hayoti davomida boshqa atopik patologiyaga aylanish tendentsiyasi bilan tavsiflanadi. Tadqiqot maqsadi. Surunkali obstruktiv bronxit muhitida atopik dermatitga uchragan bemorlar terisining morfologik xususiyatini o'rganish. Material va usullar. Tadqiqotda ADda uchragan (148) va surunkali obstruktiv bronxit bilan birga kechayotgan ADli bemor bolalarning (42) kliniko-anamnestik, laborator va terisidan olingan bioptatlarni (24) gistologik tekshirish usullari va natijalari keltirilgan. Teri strukturasidagi o'zgarishlarni o'rganish maqsadida AD va surunkali obstruktiv bronxit muhitida kasallangan bolalarning teri biopsiyalari o'rganildi. Tadqiqot natijalari Atopik dermatitga chalingan bolalarning teri biopsiyasi tahlil qilinganda, shox qatlamning invaginasiyasi, o'choqli parakeratoz, noqonuniy akantoz va tikanaksimon qatlamda hujayralararo shish, shuningdek giperkeratoz aniqlandi. Ayrim joylarda bazal qatlam hujayralarining vakuolyar distrofiyasi qayd etildi. Dermada shish va kollagen tolalarning hajm jihatdan kattalashishi, bazofil o'zgarishlari va yuqori hamda o'rta qatlam qon tomirlarining kengayishi kuzatildi. Endoteliy shishgan bo'lib, tomirlar atrofida neytrofil va eozinofillar aralashmasi bilan birga yaqqol limfogistiositar infiltratlar mavjud. Xulosa. Tadqiqot natijalari atopik dermatit va uning morfologik o'zgarishlarini tushunishda muhim ahamiyatga ega bo'lib, kasallikning diagnostikasi va terapiyasi uchun zamonaviy yondashuvlarni ishlab chiqishga yordam beradi.
Kalit so'zlar:
Mualliflar haqida
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