ИММУНОПАТОГЕНЕТИЧЕСКАЯ ОСОБЕННОСТЬ РАЗВИТИЯ ХРОНИЧЕСКОЙ БОЛЕЗНИ ПОЧЕК У ДЕТЕЙ. (обзор литературы)
Аннотация
Цель: определить значение управления цитокиновым профилем в норме и патологии у детей, в частности, в иммунопатогенетическом развитии хронической болезни почек. Заключение: различные свойства медиаторов цитокинов служат для защиты организма от инфекционных агентов и восстановления тканей. В первую очередь цитокины регулируют развитие местных защитных процессов, вызывают формирование воспалительной реакции. Поэтому состав и соотношение провоспалительных и противовоспалительных цитокинов можно рассматривать как наиболее объективные показатели воспалительного процесса и нарастания фиброза. Прогнозирование дисбаланса в системе цитокинов может быть использовано в качестве биомаркера хронического заболевания почек, прогрессирования заболевания и эффективности лечения. Анализ литературных данных выявил научную и практическую значимость изучения цитокинового статуса при хронической болезни почек.
Ключевые слова:
Об авторах
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