THE ROLE OF IL-4 AND TLR6 GENE POLYMORPHISM IN PATIENTS WITH BRONCHIAL ASTHMA WITH ALLERGIC RHINITIS

Abstract

Relevance. As is known, the occurrence of chronic diseases, such as bronchial asthma, requires a combined effect of genetic and environmental factors. At the same time, the influence of genetic predictors on the course of recurrent bronchitis in children is not excluded. The aim of the study was to study the role of IL-4 and TLR6 gene polymorphisms in patients with bronchial asthma with allergic rhinitis. Material and methods. We have studied the clinical course of bronchial asthma occurring in patients with allergic rhinitis. The observation was carried out in 130 children aged 7 to 14 years. The main group consisted of 105 people. The comparison group consisted of 45 children with allergic rhinitis with bronchial asthma and 45 children of the Republic of Belarus with biofeedback + AR. The studies were carried out on a contractual basis in the laboratory "Genotexnologiya" and at the Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan; cyto-immunological study of immunological parameters (levels of IgA, IgM, IgG, IL-4, TNF-α) in induced sputum (MI), was determined by ELISA (Russia) in the laboratory "Genotexnologiya". Results. The frequency of the unfavorable allele G, determined in the main and control groups, does not statistically significantly differ from each other χ2 = 5.754: p=0.017; OR=2.98; 95% CI 1.19-7.49). As can be seen from the presented data, a significant predominance of the C/T genotype of the C-590T polymorphism of the IL-4 gene in BA children with AR was established (22.2%, respectively, compared to 11.1% in the RB group with BOS + AR; χ2 = 1.31; p=0.4; OR=2.0; 95% CI 0.62-6.45). According to the data of statistical analysis, the association of the T/T genotype with the development of BA with AR in children was proven (χ2 =2.39; p=0.56; OR=4.87; 95%CI 0.54-43.64). Conclusions: as a result, it can be emphasized that the carriage of the polymorphic marker TLR6 745T is a genetic risk factor for the development of RB with BOS and AR, while the presence of a homozygous genotype for the minor allele 745C reduces the risk of developing BA and has protective properties.