INTERLEUKIN-6 GENE POLYMORPHISM IN FUNCTIONAL CONSTIPATION IN CHILDREN

Abstract

The authors studied the genetic marker C-174G of the IL-6 gene, the features of the distribution of the gene in functional constipation in children. The rarest genotype was homozygous for the C allele. In the group of healthy children, the C-genotype homozygous for the allele was more common than among patients. A positive association of the GG genotype (OR = 1.148) as well as the G allele (OR = 1.096) with functional constipation was shown. The presence of these allelic variants indicates an increased risk of developing functional constipation, the probability of a defect in the process of replacing guanine (G) with cytosine (C) is high.