GIPERCHOLESTEROLEMIK QUYONLARDA SULFAPORIN BILAN ENDOTELIY DISFUNKSIYASINI TUZATISH
Abstrakt
Eksperimental giperkolesterolemiyasi bo'lgan hayvonlarda, tadqiqot vaqtiga qarab, biz silliq mushak hujayralari va makrofaglarning faollashishini kuzatdik, bu esa intimada yallig'lanishning rivojlanishiga olib keladi, bu C-reaktiv oqsil (CRP), endotelin-1 va homosistein. Tadqiqotning maqsadi HCHdagi endotelial disfunktsiyaning molekulyar mexanizmlarini va ularni sulfaporin bilan tuzatish imkoniyatini o'rganish edi. Tadqiqotning materiali va usullari. Tajribalar standart dietada saqlanadigan o'rtacha vazni 2,5-3,0 kg bo'lgan 46 ta chinchilla quyonlarida o'tkazildi. Hayvonlarda eksperimental HCH modeli kungaboqar yog'ida erigan xolesterinni (CS) 3 oy davomida har kuni 1 kg tana vazniga 0,2 g nisbatda og'iz orqali yuborish orqali ko'paytirildi. Giperkolesterolemiyaning rivojlanishi biokimyoviy analizatorda aniqlangan umumiy xolesterin (TC), past zichlikdagi lipoproteinlar (LDL) va yuqori zichlikdagi lipoproteinlar (HDL) darajasining oshishi bilan baholandi. Tadqiqot natijalari. Bunday holda, homosistein darajasining progressiv o'sishi aniqlandi: 1,72 ga o'sish (P <0,01); 1, 2 va 3 oylik xolesterin qabul qilish davrlari uchun mos ravishda 2,33 (P <0,001) va 2,89 (P <0,001) marta. Giperhomosisteinemiya endotelial hujayralar tomonidan LDL ni ushlashni kuchaytirayotganini hisobga olsak, bu ko'rsatkichlar o'rtasidagi munosabatlarni o'rganish qiziqish uyg'otdi. Tadqiqotlar shuni ko'rsatdiki, LDLdagi xolesterin darajasi 2,38 ± 0,27 mmol / l bo'lsa, homosistein miqdori 3,46 ± 0,25 pg / ml ni tashkil qiladi. LDLda xolesterin darajasi 4,08 ± 0,10 bo'lgan; 5,97 ± 0,09 va 6,48 ± 0,11 mmol / l, homosistein miqdori 5,96 ± 0,05 gacha ko'tariladi; 8,07 ± 0,43 va 9,99 ± 0,17 pg/ml. Xulosa. Giperkolesterolemiya silliq mushak hujayralari va makrofaglarning faollashishi bilan namoyon bo'lib, intimada yallig'lanishning rivojlanishiga olib keladi, bu CRP, endotelin-1, homosisteinning yuqori darajasi bilan tasdiqlanadi.
Kalit so'zlar:
Mualliflar haqida
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