TUG‘MA LAB VA TANGLAY YORIG‘I BO‘LGAN ERTA YOSHDAGI BOLALAR O‘TKIR PNEVMONIYASIDA T-HELPER IMMUN JAVOBINING XUSUSIYATLARI
Abstrakt
Тakroriy o'tkir respirator infektsiyalari (ORI) va nafas yo'llari va LOR a'zolarining surunkali kasalliklari bo'lgan bolalarning katta qismi koinfektsiya tashuvchilari hisoblanadi. Maqsad: tug'ma lab va tanglay yorig'i bo'lgan erta yoshdagi bolalarning o'tkir pnevmoniyadagi Th-1/ Th-2/ Th-17 turdagi immun javoblarining asosiy sitokinlari sintezini o'rganish. Material va usullar: Ushbu tadqiqotga o'tkir pnevmoniya tashxisi qo'yilgan 38 nafar bola (taqqoslash guruhida TYLTK bilan kasallangan 18 chaqaloq va TYLTK bo'lmagan 20 bola) va 16 ta amalda sog'lom bola nazorat guruhini tashkil etdi. Qon zardobidagi interleykinlar va interferon-gamma kontsentratsiyasi Vektor-Best OAJ (Novosibirsk, Rossiya) test tizimlaridan foydalangan holda qattiq fazali ferment bilan bog'liq immunosorbent tahlil usuli bilan aniqlandi. Natijalar: O’tkir zotiljam bilan og'rigan bolalar guruhlarida ham, TYLTK tug'ma patologiyasi bo'lgan zotiljam bilan og’rigan bolalarda ham periferik qonda IL-17A, IL-4 miqdori sezilarli darajada oshgani va bolalarda IFN- γ yetishmovchiligi aniqlangan. Hayotning birinchi yilida bu immunitet tizimining nomutanosibligini ko'rsatadi va bu kasallikning kechishi va og'irligiga ta'sir qilishi mumkin. Xulosa: Pnevmoniya bilan og'rigan bolalarning barcha guruhlarida sitokin profilini qiyosiy o'rganish Th2 va Th17 immun javobining asosiy vositachilarining (IL-4 va IL-17A) gipersekretsiyasi va Th1 immun javobining asosiy virusga qarshi sitokinini (IFN γ) sintezida yetishmovchiliklar aniqlandi.
Kalit so'zlar:
Mualliflar haqida
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