FON PATOLOGIYASI BILAN NEFROTIK SINDROMLI BOLALARDA IMMUNOPATOLOGIK RIVOJLANISHINI BAHOLASH
Abstrakt
Asosiy patologiyasi bo'lgan nefrotik sindromli bolalarda immunopatologik o'zgarishlarni baholash uchun 7 yoshdan 11 yoshgacha bo'lgan 120 nafar bola tekshirildi. Ulardan: 1-guruh - NS bilan 35 bola (CGN ning nefrotik shakli); 2-guruh - LD fonida NS bo'lgan 35 bola; 3-guruh - LD bo'lgan 25 bola. Sog'lom guruh: xuddi shu yoshdagi 25 ta deyarli sog'lom bolalar. Nefrotik sindromli (surunkali glomerulonefritning nefrotik shakli) asosiy patologiya (limfa diatezi) bilan og'rigan bolalarda shishning kuchayishi (100,0%), oliguriya (100,0%), "bo'r" rangparligi kabi o'ziga xos klinik belgilar xarakterli ekanligi aniqlandi. (74,2%), anasarka (9,0%) va gepatosplenomegali (57,1%), bunga parallel ravishda og'ir anemiya rivojlanishi, kortizolning pasayishi, limfotsitozning ko'payishi, proteinuriya, fibrinogen, gamma globulin va xolesterin, kasallikning steroidga bog'liq va steroidga chidamli shakllarini rivojlanishi. Limfa diatezi bilan kechadigan nefrotik sindromda immunitetning hujayrali aloqasi etishmovchiligi, IL-2 sitokinini ishlab chiqarishning buzilishi, ASL-buyraklari, ASL-o'pkalari tarkibining ko'payishi, ular hatto saqlanib qolgan davrda ham saqlanib qoladi. kasallikning remissiyasi xarakterlidir, bu bemorlarning bunday kontingentlarini davolashda terapiyaga immunokorreksiyaning etarli usullarini kiritish zarurligini tasdiqlaydi.
Kalit so'zlar:
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