KO'P TIZIMLI ALMASHTIRISH SINDROMI, ASSOTSIATIV COVID-19 (tizimli ko'rib chiqish)
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Bolalarda ko'p tizimli yallig'lanish sindromining (MIS-C) tarqalishi 2019 yilgi koronavirus kasalligi (COVID-19) pandemiyasi boshlanganidan beri oshdi [1]. Ushbu tadqiqotning maqsadi COVID-19 bilan bog'liq mis-C ning klinik ko'rinishlari va natijalarini tavsiflash edi[2,3]. Ushbu tizimli tahlil va meta-tahlil 2022 yil 10 oktyabrgacha mavjud bo'lgan barcha adabiyotlarda o'tkazildi. Birlashgan baholarni baholash uchun jinsi, millati, klinik ko'rinishi, ventilyatsiyaga bo'lgan ehtiyoj yoki intensiv terapiya bo'limiga (ICU) yotqizish, tasvirlash, yurak asoratlari va covid-19 laboratoriya natijalari to'g'risidagi ma'lumotlar olindi[1, 4-7]. Covid-19 bilan kasallangan bolalarda multisistemali to'ldirish sindromi mavzusida 3 ta meta-tahlil o'tkazildi, unda jami 98 ta maqola (2275 bemor) demografik ma'lumotlar, klinik davolanish va MIS-C tashxisi qo'yilgan bemorlarning natijalari bilan tanlandi. MIS-C bilan kasallangan bolalarning o'rtacha yoshi, ularning 56,8% erkak edi, to'qqiz yoshda edi. Isitma (100%), oshqozon-ichak trakti (82%) va qorin og'rig'i (68%) MIS-C tashxisi uchun hal qiluvchi alomatlar edi. Shok va / yoki gipotenziya MIS-C bemorlarida tez-tez uchraydi. yurak belgilari (66%) nafas olish (39%) va nevrologik (68%) dan ustun edi.28%) alomatlar. MIS-C davolash septik shok va Kavasaki kasalligi bo'lgan bolalarni davolash bo'yicha umumiy ko'rsatmalarga javob berdi va samarali bo'ldi[8]. Hozirgi dalillarga asoslangan ushbu meta-tahlil natijalari shuni ko'rsatdiki, COVID-19 bilan bog'liq MIS-C ning umumiy klinik ko'rinishlari atipik Kavasaki kasalligi va ko'p organli disfunktsiyaga o'xshash isitma va mukokutanoz lezyonlarning kombinatsiyasini o'z ichiga oladi[9,10]. Nisbatan yuqori kasallanish va o'lim darajasi tufayli bu holatni o'z vaqtida tashxislash juda muhimdir[11].
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