Despite the obvious achievements in the study of this complex problem, a number of sections of nephrology are less studied. These diseases include glomerulonephritis and pyelonephritis. Successes in improving a systematic approach to providing medical care to children with nephrological pathology are determined primarily by in-depth knowledge of pathogenesis. The purpose of the study: to study the clinical and functional characteristics of sick children with glomerulonephritis with reduced thyroid function. Material and methods of research: The work is based on clinical observations, examination and treatment of 57 children with glomurulonephritis aged 3 to 17 years old, who were hospitalized in the neurological department of the children's clinic of the Andijan State Medical Institute during 2019-2022. The evaluation of thyroid function was carried out according to the study of the level of SBI (protein-bound iodine) by the biochemical method according to V.G. ) according to the calculation formulas, the level of TSH (thyroid-stimulating hormone) in the blood serum was studied. Results: acute and chronic glomerulonephritis with nephrotic variant in children with reduced thyroid activity was predominantly observed in school-age children, and was diagnosed much more often in boys. Analyzes characterizing the concentration of thyroid hormones in the blood serum of children with nephrotic syndrome indicate a reduced function of the thyroid gland: against the background of an increase in TSH, the levels of triiodothyronine (T3), total thyroxine (T4), protein-bound iodine (PBI), and also the coefficients of free and effective thyroxine were significantly lower. An inverse correlative, high correlation was found between the concentration of TSH and T4, SJ (respectively, r1 = -0.52, r2 = -061), which does not exclude the influence of an increased concentration of pituitary thyroid-stimulating hormone on the production of thyroid hormones. Conclusions: a characteristic feature of the clinical course of acute glomerulonephritis with a nephrotic component reduced thyroid function was the presence in most patients of a free-form and protracted course, a relatively high proportion of the transition of an acute process to a chronic one, and all patients had damage to kidney function, against the background of a violation of immunoregulatory mechanisms.

About the Authors

List of references

Iskandarova Sh. T., Chernix M. A., Atoeva M. A.. The sanitary safety of population of Chirchik and Ohangaran towns // Tashkent: "Science", 2019; 141.

Iskandarova Sh. T., Rasulova N. F., Khasanova M. I., Yusupalieva K. B. The present issues of soil polution in Uzbekistan //Tashkent: "Science", 2019; 137.

Радыш, И.В. Введение в элементологию: учебное пособие / Оренбургский гос. ун.-т. – Оренбург: ОГУ, 2017 – 183 с. Radysh, I.V. Introduction to elementology: textbook / Orenburg state. un.-t. - Orenburg: OGU, 2017 - 183 p.

World Health Organization. United Nations Children’s Fund & International Council for the Control of Iodine Deficiency Disorders. Assessment of iodine deficiency disorders and monitoring their elimination. 3rd ed. Geneva, Switzerland: WHO, 2007.

Dasgupta PK, Liu Y, Dyke JV. Iodine nutrition: iodine content of iodized salt in the United States. Environ Sci Technol. 2008 Feb 15;42(4):1315-1323. [PubMed abstract]

U.S. Food and Drug Administration. Food Labeling: Revision of the Nutrition and Supplement Facts Labels. 2016.

U.S. Department of Agriculture, Agricultural Research Service. FoodData Central, 2019

Gordon RC, Rose MC, Skeaff SA, Gray AR, Morgan KM, Ruffman T. Iodine supplementation improves cognition in mildly iodine-deficient children. Am J Clin Nutr. 2009 Nov;90(5):1264-1271. [PubMed abstract]

Ghent WR, Eskin BA, Low DA, Hill LP. Iodine replacement in fibrocystic disease of the breast. Can J Surg. 1993 Oct;36(5):453-460. [PubMed abstract]

Azizi F, Smyth P. Breastfeeding and maternal and infant iodine nutrition. Clin Endocrinol (Oxf). 2009 May;70(5):803-809. [PubMed abstract]

Kessler JH. The effect of supraphysiologic levels of iodine on patients with cyclic mastalgia. Breast J. 2004 Jul-Aug;10(4):328-336. [PubMed abstract]

Center for Drug Evaluation and Research, Food and Drug Administration. Guidance. Potassium iodide as a thyroid blocking agent in radiation emergencies. December 2001.

World Health Organization. Guidelines for Iodine Prophylaxis following Nuclear Accidents. 1999.

Nauman J, Wolff J. Iodide prophylaxis in Poland after the Chernobyl reactor accident: benefits and risks. Am J Med 1993;94:524-532. [PubMed abstract]

Pennington JA. A review of iodine toxicity reports. J Am Diet Assoc. 1990 Nov;90(11):1571-1581. [PubMed abstract]

Natural Medicines Comprehensive Database. Iodine. Accessed 10/13/2009.

How to Cite

Arzibekov А. ., Arziqulov А. ., & Arzibekova У. . (2023). CLINICAL AND FUNCTIONAL CHARACTERISTICS OF SICK CHILDREN WITH GLOMERULONEFRITIS WITH REDUCED THYROID FUNCTION. International Journal of Scientific Pediatrics, (3), 09–13.
Views: 25

Most read articles by the same author(s)