РОЛЬ ЭНДОТЕЛИАЛЬНОЙ ДИСФУНКЦИИ В РАЗВИТИИ КАРДИОВАСКУЛЯРНЫХ ОСЛОЖНЕНИЙ ПРИ АБДОМИНАЛЬНОМ ОЖИРЕНИИ У ДЕТЕЙ (литературный обзор)
Аннотация
Высокий показатель сердечно-сосудистых заболеваний у взрослых указывает на необходимость своевременной диагностики риска развития кардиоваскулярных осложнений. Понимание патофизиологических механизмов, связывающих детское и подростковое абдоминальное ожирение с сердечно-сосудистой патологией может рассматриваться как фактор кардиоваскулярного риска в последующие зрелые годы. Изучение эндотелиальной дисфункции способствует пониманию патогенетической значимости структурно-функционального состояния сосудистой стенки в повышении сердечно-сосудистых рисков, что определяет необходимость при ожирении распознавать и корректировать самые ранние признаки поражения сердечно-сосудистой системы.
Об авторах
Список литературы
Vavilova T.P., Pleten A.P., Mikheev R.K. Biological role of adipokines as markers of pathological conditions. Vopr. pitaniya. 2017; 86(2):5–13.
Golovchenko Yu.I., Treshchinskaya M.A. Review of modern concepts of endothelial dysfunction. Consil. med. Ukraina. 2010; 11:38–39.
Danilyuk L.V., Pogodina A.V., Rychkova L.V., Mashanskaya A.V. Predictors of hypertensive response to exercise in obese adolescents. Acta biomedica scientifica. 2016; 5(111):9-14.
Dedov I.I., Shestakova M.V., Melnichenko G.A., et al. Interdisciplinary clinical guidelines "Treatment of obesity and comorbid diseases". Obesity and Metabolism. 2021; 18(1):5- 99. DOI: https://doi.org/10.14341/omet12714
Evdokimova N.V., Novikova V.P., Gurina O.P., Blinov A.E., Varlamova O.N. Evaluation of markers of endothelial dysfunction in children with obesity. Forcipe. 2022; 5(2): 194 − 195.
Karpova O.B., Shchepin V.O., Zagoruychenko A.A. Prevalence of adolescent obesity in the world and the Russian Federation in 2012−2018. Hygiene and Sanitation. 2021; 100(4):365 – 372. DOI: https://doi.org/10.47470/0016-9900-2021-100-4-365-372
Kedrinskaya A.G., Kuprienko N.B., Obraztsova G.I., Leonova I.A. Structural changes in the heart and anthropometric markers of myocardial remodeling in overweight and obesity in children. Arterial hypertension. 2018;24(5):570-580. DOI: https://doi.org/10.18705/1607-419X-2018-24-5-570-580
Kedrinskaya A.G., Obraztsova G.I., Nagornaya I.I. Cardiovascular lesions in children with obesity. Arterial hypertension. 2015;21(1):6–15. DOI: https://doi.org/10.18705/1607-419X-2015-21-1-6-15
Malyavskaya S.I., Toropygina T.A., Tril’ V.E., Ternovskaya V.A. Features of the lipoprotein spectrum in girls with asymptomatic hyperuricemia. Russian journal of cardiology. 2004;№ 1: 33–37.
Maskova GS, Chernaya NL, Dadaeva OB Pathogenetic variants of vascular endothelial dysfunction development in obese adolescents. Bulletin of New Medical Technologies. Electronic publication. 2015; 4:13.
Margieva TV, Sergeeva TV Participation of endothelial dysfunction markers in the pathogenesis of chronic glomerulonephritis. Vopr. sovremennykh pediatr. 2006;5(3):22–30.
Martynov AI, Avetyak NG, Akatova EV et al. Endothelial dysfunction and methods for its determination. Russ. cardiol. j. 2005;4(54):94–98.
Mayanskaya S.D., Antonov A.R., Popova A.A., Grebenkina I.A. Early markers of endothelial dysfunction in the dynamics of arterial hypertension development in young people. Kazan Med. J. 2009;90(1):32–37.
Miroshnichenko O.M., Roytman E.I. Endothelial function in adolescents with constitutional-exogenous obesity in the dynamics of sanatorium treatment. Bulletin of Novgorod State University. 2015;2(85):114–116.
Panina I.Yu., Rumyantsev A.Sh., Menshutina M.A. et al. Features of endothelial function in chronic kidney disease. Literature review and own data. Nephrology. 2007;11(4):28–46.
Petrishchev NN Pathogenetic significance of dysfunction. Omsk. scientific vestn. 2005;13(1):20–22.
Petrishchev NN, Vlasov TD Physiology and pathophysiology of endothelium. — SPb.: SPbSMU, 2003; 438.
Pleten AP, Mikheev RK Biochemical markers in the pathogenesis of obesity (review): collection of articles. Int. scientific-practical. conf. Kazan. Aeterna. 2015;45–47.
Postnikova EV, Smirnov IE, Maslova OI, Namazova-Baranova LS Clinical and pathogenetic significance of endothelial dysfunction in the formation of obesity in children. Russian Journal of Pediatrics. 2013;5:36-40.
Smirnova NN, Kuprienko NB, Zhestyannikova EI. Endothelial dysfunction in obesity in children. Medicine: Theory and Practice. 2019; 4(2):35 ‒ 41.
Teplyakov AT, Berezikova EN, Shilov SN, et al. Evaluation of the role of hyperhomocysteinemia and methylenetetrahydrofolate reductase gene polymorphism in the development of chronic heart failure. Cardiovascular Therapy and Prevention. 2016; 15 (4): 22–24. DOI: https://doi.org/10.15829/1728-8800-2016-4-22-28
Uryasyev OM, Dubinina II, Berstneva SV, Nikiforov AA. Arterial hypertension and endothelial dysfunction in comorbid pathology: diabetes mellitus and hypothyroidism. Pavlov Russian Medical and Biological Bulletin. 2014;3:143-147.
Uryasyev OM, Nikitina IN, Pavlyuchenkova TA Endothelial dysfunction as an important link in the pathogenesis of chronic diseases. Zemsky Vrach. 2020;1:5-8.
Tsertsvadze LK, Marina Vladimirovna Avdeeva MV, Shcheglov DS, Vasilenko VS The level of endothelial dysfunction biomarkers in young men aged 18-21 years with abdominal obesity. Medicine: theory and practice. 2022;7(4):45-51. DOI: https://doi.org/10.56871/MTP.2022.65.67.005
Schwartz V.Ya. Adipose tissue as an endocrine organ. Problems of Endocrinology. 2009;55(1):38–43. DOI: https://doi.org/10.14341/probl200955138-43
Shishkin A.N., Kirilyuk D.V. Endothelial dysfunction in patients with progressive kidney disease. Nephrology. 2015;9(2):16–22.Bardugo A., Fishman B., Libruder C.Body mass index in 1.9 million adolescents and stroke in young adulthood. Stroke. 2021;52:2043 – 2052. DOI: https://doi.org/10.1161/STROKEAHA.120.033595
Bluher M. The distinction of metabolically «healthy» from «unhealthy» obese individuals. Curr. Opin. Lipidol. 2014;21(1):38–43. DOI: https://doi.org/10.1097/MOL.0b013e3283346ccc
Chambless L.E., Heiss G., Folsom A.R., Rosamond W., Szklo M., Sharrett A.R. et al. Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC). Study. Am J Epidemiol. 1997;146(6):483–494. DOI: https://doi.org/10.1093/oxfordjournals.aje.a009302
Chatterjee A., Catravas J.D. Endothelial nitric oxide (No) and its pathophysiologic regulation. Vasc. pharmacol. 2008; 49(46): 134—140. DOI: https://doi.org/10.1016/j.vph.2008.06.008
Choi K.M. The Impact of Organokines on Insulin Resistance, Inflam mation, and Atherosclerosis. Endocrinol. Metab. (Seoul). 2016;31(1):151–154. DOI: https://doi.org/10.3803/EnM.2016.31.1.1
Dangardt F., Osika W., Volkmann R., Gan L.M., Friberg P. Obese children show increased intimal wall thickness and decreased pulse wave velocity. Clin Physiol Funct Imaging. 2008;28(5):287–293. DOI: https://doi.org/10.1111/j.1475-097X.2008.00806.x
Davis P.H., Dawson J.D., Riley W.A., Lauer R.M. Carotid Intimal Medial Thickness Is Related to Cardiovascular Risk Factors Measured. From Childhood Through Middle Age: The Muscatine Study. Circulation. 2001;104(23):2815–2819. DOI: https://doi.org/10.1161/hc4601.099486
Falaschetti E., Hingorani A. D., Jones A. et al. Adiposity and cardiovascular risk factors in a large contemporary population of pre-pubertal children. European Heart Journal. 2010;31(24):3063–3072. DOI: https://doi.org/10.1093/eurheartj/ehq355
Formoso G., Taraborrelli M., Guagnano M.T. et al. Magnetic reso nance imaging determined visceral fat reduction associates with enhanced Il-10 plasma levels in calorie restricted obese subjects. PLoS One. 2012;7(12):52. DOI: https://doi.org/10.1371/journal.pone.0052774
GBD 2015 Obesity Collaborators. Health effects of overweight and obesity in 195 countries over 25 years. New England Journal of Medicine. 2017;377(1):13 ‒ 27. DOI: https://doi.org/10.1056/NEJMoa1614362
Guzik T.J., Harrison D.G. Vascular NADPH oxi dases as drug targets for novel antioxidant strategies. Drug Discovery Today. 2006;11-12:524–526. DOI: https://doi.org/10.1016/j.drudis.2006.04.003
Higashi Y., Noma K., Yoshizumi M. et al. Endothelial function and oxidative stress in cardiovascular diseases. Cir culation J. 2009;3:411–415. DOI: https://doi.org/10.1253/circj.CJ-08-1102
Hughes K. J. Meares G. P., Hansen P. A. et al. FoxO1 and SIRT1 Regulate βCell Responses to Nitric Oxide. The journal of biological chemistry. 2011; 286(10):8338–8348. DOI: https://doi.org/10.1074/jbc.M110.204768
Hsieh C.J., Wang P.W., Chen T.Y. The relationship between regional abdominal fat distribution and both insulin resistance and subclini cal chronic inflammation in non-diabetic adults. Diabetol. Metab. Syndr. 2014;6(1):49. DOI: https://doi.org/10.1186/1758-5996-6-49
Jaakonmäki N., Zedde M., Sarkanen T., Martinez-Majander N., Tuohinen S. et al. Obesity and the risk of cryptogenic ischemic stroke in young adults. Journal of Stroke and Cerebrovascular Diseases. 2022;31(5):106. DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106380
Karpoff L., Vinet A., Schuster I., Oudot C., Goret L., Dauzat M. et al. Abnormal vascular reactivity at rest and exercise in obese boys. Eur J Clin Invest. 2009;39(2):94–102. DOI: https://doi.org/10.1111/j.1365-2362.2008.02068.x
Kapiotis S., Holzer G., Schaller G., Haumer M., Widhalm H., Weghuber D. et al. A proinflammatory state Isdetectable in obese children and is accompanied by functional and morphological vascular changes. Arterioscler Thromb Vasc Biol. 2006;26(11):2541–2546. DOI: https://doi.org/10.1161/01.ATV.0000245795.08139.70
Lorenz M.W., Markus H.S., Bots M.L., Rosvall M., Sitzer M. Predictionof clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta analysis. Circulation. 2007;115(4): 459–467. DOI: https://doi.org/10.1161/CIRCULATIONAHA.106.628875
Levin E.R. Endothelins. N. Engl. J. med. 1995; 333(6):356—363. DOI: https://doi.org/10.1056/NEJM199508103330607
Mather K.J., Lteif A., Steinberg H.O. et al. Interactions between endothelin and nitric oxide in the regulation of vascular tone in obesity and diabetes. diabetes. 2004;53(8):2060—2066. DOI: https://doi.org/10.2337/diabetes.53.8.2060
Milner E.B., Pokhlebkina A.A., Leonova I.A., Khavkin A.I.. Role of the brain neutrophic factor in the genesis of obesity. Vopr. prakt. pediatr. (Clinical Practice in Pediat rics). 2021;16(1):58-63. DOI: https://doi.org/10.20953/1817-7646-2021-1-58-63
Oh K.J., Lee D.S., Kim W.K., Han B.S. et al. Metabolic adaptation in obesity and type II diabetes: myokines, adipokines and hepa tokines. Int. J. Mol. Sci. 2016;18(1) doi: 10.3390/ijms18010008 DOI: https://doi.org/10.3390/ijms18010008
O’Leary D.H., Polak J.F., Kronmal R.A., Manolio T.A., Burke G.L., Wolfson S.K. Jr. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. N Engl J Med. 1999;340(1):14–22. DOI: https://doi.org/10.1056/NEJM199901073400103
Radenković M., Stojanović M., Potpara T. et al. therapeutic approach in the improvement of endothelial dysfunction: the current state of the art . Biomed. res. Int. 2013. DOI: https://doi.org/10.1155/2013/252158
Raghuveer G. Lifetime cardiovascular risk of childhood obesity. Am J Clin Nutr. 2010;91(5):1514-1519. DOI: https://doi.org/10.3945/ajcn.2010.28701D
Reinehr T., Kiess W., de Sousa G., Stoffel-Wagner B., Wunsch R. Intima media thickness in childhood obesity: Relations to inflammatory marker, glucose metabolism, and blood pressure. Metabolism. 2006;55(1):113–118 DOI: https://doi.org/10.1016/j.metabol.2005.07.016
Rajala M.W., Qi Y., Patel H.R. et al. Regulation of resistin expression and circulating levels in obesity, diabetes, and fasting. Diabetes. 2014;53(7):1671–1679. DOI: https://doi.org/10.2337/diabetes.53.7.1671
Ramanjaneya M., Chen J., Brown J.E. et al. Identification of nesfatin 1 in human and murine adipose tissue: a novel depot-specific adipo kine with increased levels in obesity. Endocrinology. 2014;15(7): 3169–3180. DOI: https://doi.org/10.1210/en.2009-1358
Rippe C., Lesniewski L., Connell M. et al. Short term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress. Aging. Cell. 2010;9:304–312 DOI: https://doi.org/10.1111/j.1474-9726.2010.00557.x
Salam M.M., Yousuf R.M., Salam W., Haque M. Obesity and overweight: a global public health issue. Advances in Human Biology. 2023;13 (1):154. DOI: https://doi.org/10.4103/aihb.aihb_106_22
Seven E. Overweight, hypertension and cardiovascular disease: focus on adipocytokines, insulin, weight changes and natriuretic peptides. Dan. Med. J. 2015;62(11):91–97.
Smirnova N.N., Khavkin A.I., Novikova V.P., Kuprienko N.B., Belozertseva V.N., Zhestyannikova E.I. Composition of breast milk in obese mothers and its impact on the infant's development. Vopr. prakt. pediatr. (Clinical Practice in Pediatrics). 2022;17(1):166-176. DOI: https://doi.org/10.20953/1817-7646-2022-1-167-176
Sonntag D., Ali S., De Bock F. Lifetime indirect cost of childhood overweight and obesity: A decision analytic model. Obesity (Silver Spring). 2016;24(1):200-206. DOI: https://doi.org/10.1002/oby.21323
Stanley T.L., Zanni M.V., Johnsen S. et al. TNF-alpha antagonism with etanercept decreases glucose and increases the proportion of high molecular weight adiponectin in obese subjects with fea tures of the metabolic syndrome. J. Clin. Endocrinol. Metab. 2011;96(1):146–150. DOI: https://doi.org/10.1210/jc.2010-1170
Tanno M., Kuno A., Yano T. et al. Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell sur vival in chronic heart failure. J. Biol. Chem. 2010; 285(11): 8375–8382. DOI: https://doi.org/10.1074/jbc.M109.090266
Urbina E.M., Kimball T.R., McCoy C.E., Khoury P.R., Daniels S.R., Dolan L.M. Youth With obesity and obesity-related type 2 diabetes mellitus demonstrate abnormalities in carotid structure and function. Circulation. 2009;119(22):2913–2919. DOI: https://doi.org/10.1161/CIRCULATIONAHA.108.830380
Versari D., Daghini E., Virdis A. et al. Endothelium-dependent contractions and endothelial dysfunction in human hypertension. Br. J. pharmacol. 2009; 157(4):527—536. DOI: https://doi.org/10.1111/j.1476-5381.2009.00240.x
Zhang Q. J., Wang Z., Chen H. Z. et al. Endotheliumspecific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein Edeficient mice. Cardiovasc. Res. 2008; 80(2):191–199. DOI: https://doi.org/10.1093/cvr/cvn224
Как цитировать
Это произведение доступно по лицензии Creative Commons «Attribution-NonCommercial-NoDerivatives» («Атрибуция — Некоммерческое использование — Без производных произведений») 4.0 Всемирная.
