IMMUNOLOGICAL ASPECTS OF THE DIAGNOSIS OF ATROPHIC PHARYNGITIS IN CHILDREN

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Abstract

Atrophic pharyngitis in children is a common disease characterized by inflammation and atrophy of the pharyngeal mucosa. The immunological aspects of diagnosing this condition play an important role in determining the severity of the disease, predicting its course and choosing the optimal treatment strategy. The purpose of this review is to highlight the immunological aspects of the diagnosis of atrophic pharyngitis in children in order to provide a deeper understanding of the mechanisms of development and progression of this disease. Key aspects include changes in the levels of immunoglobulins, inflammatory cytokines, immunocompetent cells and their role in maintaining pharyngeal health. The development prospects include more accurate biomarkers, individualized treatment approaches, and integration with other areas of medicine. With the development of molecular diagnostic methods and medical data processing technologies, it becomes possible to create personalized treatment regimens that take into account the individual characteristics of the patient. This makes it possible to increase the effectiveness of therapy and reduce the risk of undesirable side effects. Biomarkers are key tools for the diagnosis, prediction and monitoring of various diseases. Modern technologies such as genomic sequencing and metabolomics make it possible to identify new biomarkers, which contributes to earlier detection of diseases and accurate determination of their characteristics.

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List of references

Öztürk K, Sönmez HE, Kasapçopur Ö. Periodic Fever Syndromes in Children and Hearing Loss //Hearing Loss in Congenital, Neonatal and Childhood Infections. Springer International Publishing; 2023. DOI: https://doi.org/10.1007/978-3-031-38495-0_66

Boyarchuk O, Mochulska O, Komorovsky R. Diagnosis and management of pharyngitis in children: a survey study in Ukraine. Germs [Internet]. 2021;11(3):363–71. Available from: http://dx.doi.org/10.18683/germs.2021.1273 DOI: https://doi.org/10.18683/germs.2021.1273

Jikhashvili N. Causes and peculiarities of development of chronic atrophic pharyngitis. Georgian Med News. 2020;(298):33–6.

Khosroeva NI, Kudzieva VP, Mamsurova LG, Mamsurova ZT, Khosroeva OT. Impact of environmental factors on health and population dynamics. In: Proceedings of the International Conference on Health and Well-Being in Modern Society (ICHW 2019). Paris, France: Atlantis Press; 2019. DOI: https://doi.org/10.2991/ichw-19.2019.39

Holms RD. Review of Russian ezrin peptide treatment of acute viral respiratory disease and virus induced pneumonia; a potential treatment for covid-19. 2020.

Jayaram S, Marnane C. Scott-Brown’s Otorhinolaryngology and Head and Neck Surgery. CRC Press; 2018.

Karaosmanoglu A, Akgoz B. Anatomy of the pharynx and cervical esophagus. Neuroimaging Clinics. 2022;32:791–807. DOI: https://doi.org/10.1016/j.nic.2022.07.022

Zhou X, Bi X. Practical Otorhinolaryngology-Head and Neck Surgery. Diagnosis and Treatment. 2021;163–7. DOI: https://doi.org/10.1007/978-981-13-7993-2_13

Meloyan EK, Safronenko AV, Gantsgorn EV, Krishtopa AV. Features of the «microbial landscape» of the pharynx and large intestine in patients with chronic compensated tonsillopharyngitis. jour [Internet]. 2023;4(1):90–6. Available from:http://dx.doi.org/10.21886/2712-8156-2023-4-1-90-96 DOI: https://doi.org/10.21886/2712-8156-2023-4-1-90-96

Arambula A, Brown JR, Neff L. Anatomy and physiology of the palatine tonsils, adenoids, and lingual tonsils. World J Otorhinolaryngol Head Neck Surg [Internet]. 2021;7(3):155–60. Available from: http://dx.doi.org/10.1016/j.wjorl.2021.04.003 DOI: https://doi.org/10.1016/j.wjorl.2021.04.003

Mohamed AA, Alawna M. Role of increasing the aerobic capacity on improving the function of immune and respiratory systems in patients with coronavirus (COVID-19): A review. Diabetes Metab Syndr [Internet]. 2020;14(4):489–96. Available from: http://dx.doi.org/10.1016/j.dsx.2020.04.038 DOI: https://doi.org/10.1016/j.dsx.2020.04.038

Pichichero ME. Immunologic dysfunction contributes to the otitis prone condition //Journal of Infection. :614–22. DOI: https://doi.org/10.1016/j.jinf.2020.03.017

Fan C, Guo L, Gu H, Huo Y, Lin H. Alterations in oral-nasal-pharyngeal Microbiota and salivary proteins in mouth-breathing children. Front Microbiol [Internet]. 2020;11:575550. Available from: http://dx.doi.org/10.3389/fmicb.2020.575550 DOI: https://doi.org/10.3389/fmicb.2020.575550

Drozdova MV, Preobrazhenskaya YS, Ryazantsev SV, Pavlova SS. Inflammatory diseases of the pharynx in children. Med Counc [Internet]. 2022;(1):51–7. Available from: http://dx.doi.org/10.21518/2079-701x-2022-16-1-51-57 DOI: https://doi.org/10.21518/2079-701X-2022-16-1-51-57

Wekell P. Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome-PFAPA syndrome. La Presse Médicale. 2019;48:e77–87. DOI: https://doi.org/10.1016/j.lpm.2018.08.016

Kaur G, Mohindra K, Singla S. Autoimmunity-Basics and link with periodontal disease. Autoimmun Rev [Internet]. 2017;16(1):64–71. Available from: http://dx.doi.org/10.1016/j.autrev.2016.09.013 DOI: https://doi.org/10.1016/j.autrev.2016.09.013

Li Y. The effects of secretory IgA in the mucosal immune system //BioMed research international.

Chen K, Magri G, Grasset EK, Cerutti A. Rethinking mucosal antibody responses: IgM, IgG and IgD join IgA. Nat Rev Immunol [Internet]. 2020;20(7):427–41. Available from: http://dx.doi.org/10.1038/s41577-019-0261-1 DOI: https://doi.org/10.1038/s41577-019-0261-1

Troshina EA. The role of cytokines in the processes of adaptive integration of immune and neuroendocrine reactions of the human body. Probl Endokrinol (Mosk) [Internet]. 2021;67(2):4–9. Available from: http://dx.doi.org/10.14341/probl12744 DOI: https://doi.org/10.14341/probl12744

Tian T, Wei B, Wang J. Study of C-reactive protein, procalcitonin, and immunocyte ratios in 194 patients with sepsis. BMC Emerg Med [Internet]. 2021;21(1):81. Available from: http://dx.doi.org/10.1186/s12873-021-00477-5 DOI: https://doi.org/10.1186/s12873-021-00477-5

Ma J, Lu Q, Tu S, Miao X, Zhao J. A diagnostic test: combined detection of heparin-binding protein, procalcitonin, and C-reactive protein to improve the diagnostic accuracy of bacterial respiratory tract infections. J Thorac Dis [Internet]. 2022;14(3):721–8. Available from: http://dx.doi.org/10.21037/jtd-22-260 DOI: https://doi.org/10.21037/jtd-22-260

Orwah M, Erickson AR. IgG-4 related disease: an introduction. Missouri medicine. 2018;115. Yang H, Li J, Wang Y, Ye S, Li J. Distribution characteristics of elevated serum immunoglobulin G4 (IgG4) and its relationship with IgG4-related disease. Scand J Rheumatol [Internet]. 2019;48(6):497–504. Available from: http://dx.doi.org/10.1080/03009742.2019.1602882 DOI: https://doi.org/10.1080/03009742.2019.1602882

Thompson TZ, McMullen AR. Group A streptococcus testing in pediatrics: The move to point-of-care molecular testing. J Clin Microbiol [Internet]. 2020;58(6). Available from: http://dx.doi.org/10.1128/JCM.01494-19 DOI: https://doi.org/10.1128/JCM.01494-19

Tanz RR, Zheng XT, Carter DM, Steele MC, Shulman ST. Caution needed: Molecular diagnosis of pediatric group A streptococcal pharyngitis. J Pediatric Infect Dis Soc [Internet]. 2018;7(3):e145–7. Available from: http://dx.doi.org/10.1093/jpids/pix086 DOI: https://doi.org/10.1093/jpids/pix086

Mogoanta C, Aurelia E, Ionita M. Adenotonsillar Disease: Treatment Comes from Histo-Physio-Pathology. HANDBOOK OF PHARYNGEAL DISEASES: ETIOLOGY, DIAGNOSIS AND TREATMENT.

Arifov SS, Khasanov SA. Aspects of Diagnostics and Treatment of Chronic Tonzillitis in Elderly and Senier Patients //Annals of the Romanian Society for Cell Biology. :6862–74.

Vavilova VP, Alexander M, Vavilov SA. Leading-edge non-specific prevention of a new coronavirus infection and acute respiratory infections of other etiology. Pediatrics Consilium Medicum. 2022;3:213–22. DOI: https://doi.org/10.26442/26586630.2022.3.201800

How to Cite

Ochilov Т. ., & Khushvakova Н. . (2024). IMMUNOLOGICAL ASPECTS OF THE DIAGNOSIS OF ATROPHIC PHARYNGITIS IN CHILDREN. International Journal of Scientific Pediatrics, 3(3), 516–522. https://doi.org/10.56121/2181-2926-2024-3-3-516-522
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