BIOCHEMICAL CHANGES IN HEMOLYTIC DISEASE OF THE NEWBORNS AND THEIR RELATIONSHIP WITH CLINICAL SYMPTOMATICS (literature review)
Abstract
Complex pathophysiological changes in the maternal-placental, fetal-infant system are reflected in a number of diseases of the perinatal period, in particular, this concerns hemolytic disease of the newborn. This review article presents modern literature data on biochemical changes in hemolytic disease of the newborn and its relationship with clinical symptoms. Based on an in-depth analysis of the literature on the identification of risk factors and the mechanism of formation of the pathological process due to incompatibility of the fetus and mother by erythrocyte antigens: the Rhesus system, ABO or more rare factors with subsequent immunological conflict, objective early methods of diagnosing hemolytic disease of the newborn, it can be concluded that, to date, have not been finally resolved, a comprehensive study is required of background conditions that provoke the development of complications even with relatively low rates of hyperbilirubinemia, in particular, dyselectrolytemia and immaturity, which can be the basis for our further research.
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