MORPHOLOGICAL CHANGES OF THE HEART WALL WHEN MEXIDOL IS USED IN EXPERIMENTAL HYPOTHYROIDISM

Abstract

Relevance. There are systemic consequences of hypothyroidism on the heart among other organs. It could cause modifications to heart rate, contractility, and relaxation, among other aspects of cardiac function. The structural alterations of the heart, such as the hypertrophy (enlargement) of the heart muscle cells, may be influenced by hypothyroidism. Purpose of the study identification of morphological and functional features of postnatal development and formation of the myocardium of offspring obtained under conditions of experimental hypothyroidism in the mother. Тhe object of the study was female white outbred rats and their offspring on 3,7,14,21 and 30 days after birth. Experimental hypothyroidism in female rats was modeled by introducing mercazolil before pregnancy. The myocardium of the heart was studied using morphological, morphometric and electron microscopic research methods. Thus, analysis of the results of the study showed that the offspring of rats born to mothers with experimental hypothyroidism, starting from the 14th day after birth, develop vascular disorders in the myocardium, degenerative changes in the form of intracellular myocytolysis, disbandment of myofibrils, interstitial edema, and fragmentation of muscle fibers. Conclusions: experimental hypothyroidism reproduced in female rats leads to a pronounced disruption of the morphofunctional formation of the offspring myocardium and is a risk factor for the development of cardiovascular diseases.