HOMILADORLIKNING BIRINCHI TRIMESTRIDA ODATIY HOMILA KO‘TARA OLMASLIKNING MUDDATLARIGA KO‘RA DETSIDUAL TO‘QIMANING PATOMORFOLOGIK VA IMMUNOGISTOKIMYOVIK XUSUSIYATLARI
Abstrakt
Annotatsiya. Homiladorlikning birinchi trimestrida odatiy homila ko‘tara olmaslikda gravidar endometriyning patomorfologik xususiyatlari fibroblastsimon hujayralar va predetsidual hujayralarga differensiatsiyasi va o‘zgarishi homiladorlikning asoratlanmagan davridagi hujayralardan sitologik xilma-xilligi va polimorfik ko‘rinishi bilan farq qildi. Tadqiqot maqsadi: Homiladorlikning birinchi trimestrida odatiy homila ko‘tara olmaslikda bachadon endometriysi detsidual qavatining klinik-morfologik va immunogistokimyoviy xususiyatlarini o‘rganib, patologik o‘zgarishlarni aniqlash algoritmini yaratishdan iborat. Tadqiqot material va usullari: RIO va RIATM Xorazm filiali va Xorazm viloyati Perinatal markazida 2021-2023 yillar davomida Homiladorlikning birinchi trimestrida odatiy homila ko‘tara olmaslikda bachadon bo‘shlig‘i kyuretaji va aspiratsiyasi bajarilgan ayollar bachadonidan olingan qirindi tekshirildi. Bachadon kyuretaji yoki aspiratsiyasi yuli bilan olingan to‘qimalardan shu kunning o‘zida kesmalar olindi. Materiallarga biopsiya va operatsion materiallarni gistologik tekshirish usullari unifikatsiyasi Thermo Fisher Scientific gistoprotsessorida 16 soat davomida ko‘rsatmaga mos ravishda ishlov berildi. Natijalar: Immunogistokimyoviy tadqiqot natijasiga ko‘ra, asosiy guruhga nisbatan Ki 67 oqsili va SD34 ekspressiyasi nazorat guruhida yuqori bo‘ldi. Bu homila tushishida detsidual qobiqda proleferativ jarayonlarning sustligi va tomir adgeziyasi pastligi natijasida yuzaga kelishini bildirdi. Xulosa: aniqlangan o‘zgarishlar patomorfologlar, akusher-ginekologlar, immunologlar tomonidan ayollarda homila ko‘tara olmaslik rivojlanishining patomorfologik mexanizmlarini aniqlash uchun muammoni qo‘shimcha o‘rganishni talab qiladi. Immunogistokimyo gormonlarni davolash samaradorligini aniqroq tashxislash va nazorat qilish imkonini beradi, bemorga induvidual yondashuvni ta’minlaydi va shuning uchun gormon terapiyasi sxemalarini optimallashtirishga imkon beradi.
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