ENDOMETRIOZLARNI IMMUNOGISTOKIMYOVIY O’ZGARISHLARI TAVSIFI
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Endometriozni etio-patogenezini o’rganishda eutopik va ektopik endometriyaning molekulyar-biologik o’ziga xosligi – esterogen va progestoron resteptorlarini ekspressiyasi, proliferastiyasi, apoptozi, adgeziyasi, angiogenezi, hujayra invaziyasi markerlarini o’rganish perspektiv yo’nalishlardan hisoblanadi. Ishning maqsadi: Reproduktiv yoshdagi ayollarda boshqa ginekologik patologiyalarsiz xayz davrining proliferativ bosqichidagi adenomioz va tuhumdon endometriozidagi molekulyar-biologik xususiyatlarini o’rganish. Material va uslublar: Ushbu tadqiqotda 2019-2022 yillar mobaynida gisterektomiya qilingan menopauzagacha (18-51yosh 60-ta bioptat) va postmenopauza davridagi ayollar bioptatlariga (51 va undan katta yoshdagilar, 20-ta bioptat) immunogistokimyoviy usullarda tekshirildi. Ushbu tadqiqotda 2019-22 yilda AVPAB tekshirilgan 80ta adenomioz va tuhumdonlar endometriozlari bioptatlarini immunogistokimyoviy tekshiruvida estrogen va progesteron gormonal faoliyatni buzilishi 60-90% holatlarda progesteron, 50-70% holatlarda estrogen gormoni bachadon adenomiozi rivojlanishda va bachadonning bezli giperplaziyasiga olib kelishi, buni natijasida bemorlarda bachadon endometriysini atipik rivojlanishi va xavfli o’sma kasalligiga o’tishi kuzatildi. Ki-67 va r53 postmenopauzada davridagi 20% bemorlarda bachadonning boshlang’ich yomon sifatli o’sma holatiga o’tganligi bilan namoyon bo’ldi.
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