DEMOGRAPHIC AND BLOOD CIRCULATING MATERNAL FACTORS IN PREGNANT WOMEN WITH EARLY AND LATE PRE-ECLAMPSIA

Abstract

Preeclampsia, one of the “life-threatening obstetric syndromes,” complicates approximately 2–7% of pregnancies and is considered a leading cause of maternal and perinatal morbidity and mortality worldwide. Purpose of the study. Comparison of the profile of circulating angiogenic (i.e., PlGF) and antiangiogenic (i.e., sVEGFR-1 and cardiolipin GPLC, phospholipid GPLF, and leptin GPLL) factors in patients with late-onset preeclampsia (LOPE) and in patients with severe early-onset preeclampsia ( RNPE). Material and methods. A cross-sectional study was conducted by screening biological samples (n=116) from pregnant women. All examined patients were divided into the following groups: 1) patients with normal pregnancy (n=40); 2) severe RNPE (n=40); and 3) PNPE (n=36). Results: Studying the relationship in combinations involving leptin + antiplacental factor VEGFR-1 increases the diagnostic value of RNPE. In addition, the various ratios were not significantly associated with PE after adjusting for maternal age and gestational age at the time of blood collection. Conclusions: 1) At the time of diagnosis, the median concentrations of sVEGFR-1 and sVEGFR-1, leptin GPLL in maternal serum were significantly higher (P>0.001), and PlGF significantly lower (P>0.001) in patients with RNPE and PNPE than in women with a normal pregnancy; 2) Similarly, the ratios PlGF/sVEGFR-1, PLGF/ leptin GPLL, PLGF/( leptin GPLL × sVEGFR-1) and PLGF/( leptin GPLL + sVEGFR-1) were significantly lower in patients with RUPE and PNPE than in patients with normal pregnancy; 3) Median concentrations of leptin GPLL and the ratio PLGF/ leptin GPLL, PLGF/( leptin GPLL + sVEGFR-1) were significantly high in patients with RNPE (P>0.001) versus the indicators in patients with PNPE.