ERTA VA KECHGI PREEKLAMPSIYA BO'LGAN HOMILADOR AYOLLARDA DEMOGRAFIK VA QON AYLANMASINING ONALIK OMILLARI.
Abstrakt
"Hayot uchun xavfli akusherlik sindromlari" dan biri bo'lgan preeklampsi homiladorlikning taxminan 2-7 foizini murakkablashtiradi va butun dunyo bo'ylab onalar va perinatal kasalliklar va o'limning asosiy sababi hisoblanadi. Tadqiqot maqsadi. Kech boshlangan preeklampsi (LOPE) bilan og'rigan bemorlarda va og'ir kechikish bilan og'rigan bemorlarda aylanma angiogenik (ya'ni, PlGF) va antiangiogenik (ya'ni, sVEGFR-1 va kardiolipin GPLC, fosfolipid GPLF va leptin GPLL) profilini taqqoslash. preeklampsi (RNPE). Materiallar va usullar. Homilador ayollardan biologik namunalarni (n=116) skrining qilish orqali kesma tadqiqot o'tkazildi. Barcha tekshirilgan bemorlar quyidagi guruhlarga bo'lingan: 1) normal homilador bo'lgan bemorlar (n=40); 2) og'ir RNPE (n=40); va 3) PNPE (n=36). Natijalar: Leptin + antiplasental omil VEGFR-1 ishtirokidagi kombinatsiyalardagi munosabatlarni o'rganish RNPE ning diagnostik qiymatini oshiradi. Bundan tashqari, qon to'plash vaqtida onaning yoshi va homiladorlik yoshiga moslashtirilgandan so'ng, turli nisbatlar PE bilan sezilarli darajada bog'liq emas edi. Xulosa: 1) Tashxis qo'yish vaqtida ona zardobidagi sVEGFR-1 va sVEGFR-1, leptin GPLL ning o'rtacha kontsentratsiyasi sezilarli darajada yuqori (P>0,001) va RNPE va RNPE bilan og'rigan bemorlarda PlGF sezilarli darajada past (P>0,001) edi. PNPE normal homilador ayollarga qaraganda; 2) Xuddi shunday, PlGF/sVEGFR-1, PLGF/leptin GPLL, PLGF/(leptin GPLL × sVEGFR-1) va PLGF/(leptin GPLL + sVEGFR-1) nisbatlari RUPE va PNPE bilan og'rigan bemorlarda sezilarli darajada past edi. normal homiladorlik bilan; 3) Leptin GPLL ning o'rtacha konsentratsiyasi va PLGF/leptin GPLL, PLGF/(leptin GPLL + sVEGFR-1) nisbati RNPE (P>0,001) bilan og'rigan bemorlarda PNPE bilan og'rigan bemorlardagi ko'rsatkichlarga nisbatan sezilarli darajada yuqori edi.
Kalit so'zlar:
Mualliflar haqida
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