DISMICROELEMENTOSIS IN CHILDREN WITH BRONCHIAL ASTHMA AND THEIR DIAGNOSTIC SIGNIFICANCE
Abstract
The aim of the study was to study the possible pathogenetic mechanisms of the formation of bronchial hyperreactivity in bronchial asthma associated with microelementoses. The study group consisted of 45 children with bronchial asthma. The research methods were the method of neutron activation analysis of the content of trace elements in hair and the method of atomic absorption spectrometry of blood serum. The state of bronchial hyperreactivity was accompanied by a deficiency of essential microelements (69.6%) in severe bronchial asthma, against the background of selenium and zinc deficiency (plasma levels below 0.2 and 0.35 mg/l, respectively), and a decrease in the speed parameters of the function of external respiration.
Keywords:
About the Authors
List of references
Chernyak B.A., Vorzheva I.I., Sukmanskaya E.O. Asthma. - 2020. - Vol. 1 (31). — pp. 69–77.
Koh Y. Y. Bronchial hyperresponsiveness in adolescents with long-term asthma remission: importance of a Family history of bronchial hyperresponsiveness / Y. Y. Koh, E. K. Kang, H. Kang // Chest. - 2015. - Vol. 124, No. 3. - P. 819-825. DOI: https://doi.org/10.1378/chest.124.3.819
Molokova A. V. Clinical and pathogenetic aspects of hyperreactivity of the bronchial tree in children with atopic dermatitis in combination with bronchial asthma: author. dis. ... Dr. med. Sciences / A. V. Molokova. - Novosibirsk, 2014. - 36 p.
Pavlenko N. S. Clinical, immunological and metabolic features of atopic dermatitis in children with selenium and zinc deficiency: author. dis. ... cand. honey. Sciences / N. S. Pavlenko. - Novosibirsk, 2021. - 21 p.
Mineral homeostasis and respiratory disorders in children with bronchial asthma / T. G. Reshetova [et al.] // Pulmonology of childhood: problems and solutions, no. 2. - Moscow-Ivanovo, 2020. - P. 140–142.
Barbarino F. Zinc and T-lymphocyte subsets in patients with pulmonary diseases / F. Barbarino, E. Toganel, A. Cocarla // Trace Elements in Man and Animals - TEMA - 8 / Eds. M. Anke, D. Meissner, C. F. Mils. - Dresden, 1993. - P. 890-891.
Beasley R. Selenium, glutathione peroxidase and asthma / R. Beasley // Clin. Exp. Allergy. - 1991. - P. 157-159 DOI: https://doi.org/10.1111/j.1365-2222.1991.tb00824.x
Richter M. Zinc status modulates bronchopulmonary eosinophil infiltration in a murine model of allergic inflammation / M. Richter, R. Bonneau, M. A. Girard // Chest. - 2018. - Vol. 123 (3 Suppl). — P. 446. DOI: https://doi.org/10.1378/chest.123.3_suppl.446S
Vural H. Concentrations of copper, zinc and various elements in serum of patients with bronchial asthma / H. Vural, K. Uzun, E. Uz // J. Trace Elem. Med. Biol. - 2020. - Vol. 14(2). — P. 88–91. DOI: https://doi.org/10.1016/S0946-672X(00)80036-X
Immunopharmacology of trace elements / A. V. Kudrin [et al.]. - M. : KMK Publishing House, 2020. - 537 p.
Rustembekova S. A. Microelementoses and environmental risk factors / S. A. Rustembekova, T. A. Baraboshkina. — M.: Logos, 2016. — 196 p.
Boulet L. P. Physiopathology of airway hyperresponsiveness / L. P. Boulet // Curr. Allergy Asthma Rep. - 2013. - Vol. 3, No. 2. — P. 166–171. DOI: https://doi.org/10.1007/s11882-003-0030-9
Standardization of tests for the study of pulmonary function / A. G. Chuchalin [et al.]. — M.: Pulmonology, 1993. — S. 60–86.
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.