IMMUNOLOGICAL AND FUNCTIONAL FEATURES OF THE URINARY SYSTEM ORGANS IN PREMATURE CHILDREN BORN TO MOTHERS WITH PRE-ECLAMPSIA

Abstract

This article discusses the features of functional and immunological disorders of the kidneys in newborns born prematurely to mothers with preeclampsia and the processes of further functional formation of the kidneys. Kidney functions were studied in 40 premature infants in the early neonatal period (creatinine, urea, electrolytes and blood serum protein, daily diuresis, GFR).         The clinical diagnostic and prognostic value of determining the cytokines INF-γ, INF-α in the urine, the tendency of premature babies to hyponatremia in the first day of life, which indicates a low concentration function of the kidneys, has been proven. It has been established that in premature babies from mothers with preeclampsia, damage to the glomerular apparatus, manifested by a decrease in the glomerular filtration rate, edematous syndrome and an increase in creatinine concentration, has a short-term character and normalizes against the background of ongoing therapy. The clinical diagnostic and prognostic value of determining the cytokines INF-γ, INF-α in urine has been proven.