BOLALARDAGI GIPOKSIYA VA UNING METABOLIZMAGA TA’SIRI
Abstrakt
Jahon sog‘liqni saqlash tashkiloti ma’lumotlariga ko‘ra, ortiqcha vaznli va semiz bolalar soni ortib bormoqda, bu esa sog‘liqni saqlash tizimiga jiddiy tahdid solmoqda. Ilmiy tadqiqotlar shuni ko'rsatadiki, noto'g'ri ovqatlanish va homilaichi gipoksiyasi homilada neyroendokrin mexanizmining regulyasiyasiga ta'sir qilishi mumkin. Tadqiqot maqsadi. Gipoksiyani boshdan kechirgan bolalarda metabolik buzilishlarning asosiy xavf omillarini o'rganish. Materiallar va usullar. Tadqiqotda ekzogen konstitutsiyaviy semizlik va arterial gipertenziya bilan og'rigan 55 nafar o'smir ishtirok etdi. Ishtirokchilar tana massasi indeksi (TMI) va bel atrofi aylanasi 97 foizdan oshganini hisobga olgan holda tanlandi. Qon zardobidagi umumiy xolesterin va yuqori zichlikdagi lipoproteinlar darajasini aniqlash fermentativ usulda, triglitseridlar konsentratsiyasi esa modifikasiyalangan Gotfrid va Rozenberg usuli bo‘yicha kolorimetrik usulda aniqlandi. Tadqiqot natijalari va ularni muhokama qilish. Tekshirilayotgan bolalarda TMI 97 foizdan oshdi, o'rtacha 31,27 ± 0,51 kg / m² (23,5-47,2 kg / m²). I guruhda o'rtacha TMI 28,85 ± 0,52 kg / m² va II guruhda 35,37 ± 0,63 kg / m² (P <0,01) ni tashkil etdi. Lipid profili parametrlari semizlik aniqlangan bemorlarda sezilarli og'ishlarni ko'rsatdi. I, IIA va IIB guruhlaridagi bolalarning 29,4%, 30% va 38,8% triglitseridlar darajasi normadan oshdi. O'rtacha glyukoza miqdori normal oraliqda qoldi (p<0,05), ammo insulinrezistentlik aniqlandi. Ochlikdagi glikemiya kontsentratsiyasi (p<0,05) nazorat guruhidagi qiymatlardan sezilarli darajada yuqori edi va semirishning rivojlanishi bilan ortdi. 1, 2a va 2b guruhlaridagi bolalarning 17,6%, 20% va 27,7% da ochlikdagi glyukoza darajasining oshishi kuzatildi. Xuddi shunday, bolalarning 5,8%, 15% va 22,2% da postprandial glikemiyaning ko'payishi aniqlandi. Xolesterin fraktsiyalarini o'rganishda ularning darajasi 3,04±0,23, 3,66±0,18 va 4,14±0,39 mmol/l bo'lgan. Ko'tarilgan qiymatlar 29,4%, 35% va 44,4% bolalarda qayd etilgan. Tadqiqotlar 1, 2a va 2b guruhlaridagi tekshirilgan bolalarning mos ravishda 17,6%, 25% va 22,2% da yuqori zichlikdagi lipoproteinlar darajasining pasayishini aniqladi. Xulosa. Bolani tug'ilishdagi tana vazni va o'smirlik davrida tana massasi indeksi teskari korrelyatsiyaga ega ekanligi aniqlandi va kam vazn bilan tug’ilish kelajakda semizlik va metabolik sindromning prediktori sifatida ahamiyatga ega. Natijalar xavf omillarini erta aniqlash va korreksiyalash, shu jumladan hayotning birinchi kunlaridan boshlab vaznni nazorat qilish muhimligini ko’rsatadi.
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