Spastic Diplegia (Juber Syndrome) In a CHild With Coronary Circulatory Disorder And Anemia

Abstract

Introduction. In recent years, comprehensive evaluation of clinical and instrumental features of cerebral palsy (CP), taking into account perinatal risk factors and comorbid somatic conditions influencing neurological severity, has gained particular importance. Early hypoxic-ischemic brain injury remains one of the leading causes of spastic forms of CP. The aim of the study. To present a clinical case of spastic diplegia in a child and to assess clinical and instrumental characteristics of the disease course, including the impact of concomitant anemia on neurological status. Materials and Methods. The study is based on clinical observation of a female patient born in 2011 diagnosed with spastic diplegic cerebral palsy and hospitalized at the multidisciplinary clinic of Tashkent State Medical university in 2026. Clinical-neurological examination, laboratory tests (complete blood count, biochemical analysis), and instrumental studies (EEG, EchoEG, ECG) were performed. Brain MRI data were also analyzed. Results and Discussion. The patient demonstrated signs of spastic hemiparesis predominantly affecting the left side, hyperreflexia, pathological reflexes, and delayed psychomotor and speech development. MRI revealed periventricular gliosis. EEG showed dysfunction of midline brainstem structures. Moderate anemia was detected (hemoglobin 88 g/L). These findings correspond to the typical course of spastic cerebral palsy associated with hypoxic-ischemic injury of periventricular white matter. Concomitant anemia may aggravate cognitive impairment due to chronic tissue hypoxia. Conclusion. The presented clinical case confirms the role of early hypoxic-ischemic CNS injury in the development of spastic diplegia. Concomitant anemia requires correction within comprehensive therapy, as it may worsen cognitive outcomes. A multidisciplinary approach is essential for patient stabilization and functional improvement.