STATE OF CELLULAR IMMUNITY IN PATIENTS WITH OBSTRUCTIVE BRONCHITIS
Abstract
Annotation.
Obstructive bronchitis in children represents a serious medical and social problem, since they occupy one of the first places among the causes of childhood diseases. Despite many studies, the problem of obstructive bronchitis in frequently ill children remains not fully resolved, which is associated with the difficulty of timely diagnosis, peculiarities of clinical manifestations and laboratory data. The purpose of the scientific research is to study the state of cellular immunity in patients with obstructive bronchitis. Materials and research methods: to establish the relationship with indicators of cellular immunity, 80 patients with obstructive bronchitis were examined, divided into 2 groups: Group I - 40 patients with obstructive bronchitis, Group II - 40 patients with obstructive bronchitis in frequently ill children. Results: The results of the immunological study indicated disturbances in the T-cell immunity, expressed in a decrease in CD3, CD4, and a tendency towards a decrease in CD8, indicating the presence of a secondary immunodeficiency state in patients, possibly due to frequent respiratory diseases. The most informative indicators of the risk of a pathogenetically unfavorable increase in the cellular immune response in AOB are a decrease in the CD3+, CD4+, CD8+ subpopulation.
Conclusions. This study allows us to better understand the pathogenetic role of the immune status in the development of obstructive bronchitis in children, for use in clinical practice and the development of more effective methods for diagnosing, prognosis and treatment of the disease.
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List of references
Kasokhov TB, Alborova AB, Mazur AI, Tsareva AA, Kasokhova BB. The Importance Of Indicators Of Local And Systemic Immunity In The Development Of Obstructive Bronchitis In Children And Treatment Methods. Literature Review 2020:3–8.
Shamsiev A.M. Yusupov Sh. A., Yuldashev B. A., Mukhamadieva L. A. The state of the immune status in children with chronic bronchitis. Pediatric Bulletin of the Southern Urals 2017:84–9.
Ibragimova M. F. Diagnostic criteria for pneumonia of atypical etiology in children. British Medical Journal 2022;2.
Castro-Rodriguez JA, Mallol J, Rodriguez J, Auger F, Andrade R. Risk factors for X-ray pneumonia in the first year of life and its relation to wheezing: a longitudinal study in a socioeconomic disadvantaged population. Allergol Immunopathol (Madr) 2008;36:3–8. https://doi.org/10.1157/13115664. DOI: https://doi.org/10.1157/13115664
N.K. K. DYNAMICS OF IMMUNITY INDICATORS IN CHILDREN WITH OBSTRUCTIVE BRONCHITIS. Modern Issues Of Biomedicine 2022;6:20–5. DOI: https://doi.org/10.51871/2588-0500_2022_06_01_2
Lukianenko N, Kens O, Nurgaliyeva Z, Toguzbayeva D, Sakhipov M. Finding a molecular genetic marker for the incidence of recurrent episodes of acute obstructive bronchitis in children. J Med Life 2021;14:695–9. https://doi.org/10.25122/jml-2021-0052. DOI: https://doi.org/10.25122/jml-2021-0052
Sachkova LA, Balashov AL, Trukhmanov MS. OFTEN SICK CHILDREN. University Therapeutic Bulletin 2020;2:75–85.
Fedorovna IM. THE INFLUENCE OF RISK FACTORS ON THE DEVELOPMENT OF ATYPICAL PNEUMONIA IN YOUNG CHILDREN. Asian Journal of Pharmaceutical and Biological Research 2022;11.
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