CLINICAL CHARACTERISTICS OF THE NEONATAL PERIOD AND MICROELEMENTAL COMPOSITION OF THE BLOOD SERUM IN PREMATURE INFANTS WITH POST-HYPOXIC ENCEPHALOPATHY AND INTERNUTRAL DEVELOPMENT REST

Abstract

To date, the influence of the balance of the content of essential MEs on the ability of children to adapt to the physiological course of this period and the implementation of pathological syndromes has not been sufficiently studied. The purpose of the study is to study the relationship between the deficiency of certain microelements and the risk of violations during the period of early neonatal adaptation in newborns with perinatal posthypoxic encephalopathy. Material and methods of research: To solve the set tasks, 131 "mother-child" pairs in the neonatal period were under our dynamic supervision. To determine the content of microelements in blood serum, we used a photometric-colorimetric method, using kits from the Italian company "Sentinal Diagnastics" and control materials from the company "Randox Laboratorics LTD". In the examined women, depending on the gestational age and parity of pregnancy, the serum concentration of Zn, Fe, Cu and Mg was determined in the III trimester. In children, the dynamics of serum levels of Zn, Fe, Cu and Mg was studied in the early neonatal period: at birth (1st study), day 3 of life (2nd study) and on days 5-7 of life (3rd study). ). Conclusions: The greatest risk of severe complications of neonatal adaptation in the form of AEDs was found in premature infants with low levels of Zn and Mg. Prognostic clinical and laboratory criteria for disorders of ME homeostasis in newborns are: prematurity, the content of erythrocytes and hemoglobin in the blood on the 1st day of life, Apgar score in the first minute, low birth weight, levels of Zn, Fe, Cu and Mg in the blood of mothers , chronic diseases of the gastroduodenal system, the presence of microelementoses in the blood serum of a pregnant woman.