DAUN SENDROMLI ONАLARDA SIKLIN B1 NING EUVPLODIK BOLALARGA QIYOSLASH
Abstrakt
Daun sindromi (DS) eng keng tarqalgan xromosomaopatiya hisoblanadi. Siklin B1 mitozda ishtirok etadigan tartibga soluvchi oqsildir. Maqsad diabetik bemorlarning onalarida siklin B1 ning nisbiy ifodasini aniqlash edi. Usullari. Ushbu kesma tadqiqotda 2019 va 2021 yillar oralig'ida tasdiqlangan qandli diabet bilan kasallangan 40 ta onadan va 40 ta evloidli bemorlarning onalaridan periferik qon mononuklear hujayralari olindi. Demografik o'zgaruvchilar va siklin B1 xabarchi RNK (mRNK) real vaqtda polimeraza zanjiri reaktsiyasi (qPCR) orqali tahlil qilindi. DS bilan kasallangan onalarning holatlari euploid guruhining nisbiy ifodasi bilan taqqoslandi. Natijalar. RT-PCR bo'yicha siklin B1 ning o'rtacha nisbiy ifodasi diabet bilan og'rigan bolalarning onalar guruhi va euploid bolalarning onalari o'rtasida sezilarli farqni ko'rsatdi (p <0,05). Euploidli bemorlarda siklin B1 ifodasi o'rtacha darajadan past edi. Qandli diabet bilan og'rigan bemorlarda siklin B1 ifodasining pasayishi telomer qisqarishini tezlashtirishi kerakligi haqida avval xabar berilgan edi. Shuning uchun onaning yoshi bilan bog'liq xavf omilini qayta tasniflash o'rinli bo'ladi. Xulosa. Cyclin B1 reproduktiv yoshdagi ayollarda xronologik yoshga bog'liq bo'lmagan diabet holatlarini aniqlash uchun iqtisodiy jihatdan samarali biomarker bo'lishi mumkin.
Kalit so'zlar:
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