SURUNKALI VIRUSLI GEPATITDA SITOKINLARNING PROGNOSTIK AHAMIYATI
Abstrakt
Mazkur maqolada surunkali gepatit bilan og'rigan bemorlarda sitokin profilini o'rganish natijalari keltirilgan va asoratlarni oldini olish uchun ma'lumot beruvchi belgilar ishlab chiqilgan. Tadqiqot natijalari umumiy amaliyot shifokorlari va yuqumli kasalliklar bo'yicha mutaxassislar va oilaviy poliklinikalar va birlamchi sog'liqni saqlash darajasidagi Markaziy tuman poliklinikalarining terapevtlarini amaliy faoliyatga keng joriy etish uchun tavsiya etiladi. Tadqiqotning maqsadi: surunkali virusli gepatitlarda sitokinlarni o'rganish, ularning asoratlarining bashoratli ko'rsatkichlarini ishlab chiqish. Materiallar va tadqiqot usullari. Tadqiqotga atigi 64 nafar bemor kiritilgan, ulardan 38 yoshdan 79 yoshgacha bo'lgan 30 nafar bemor (1-guruh) va 31 yoshdan 67 yoshgacha bo'lgan surunkali virusli gepatit b (XVGV) -34 nafar bemor (2-guruh)surunkali virusli gepatit C (XVGS) bilan kasallangan. Bunda, bemorlarning o'rtacha yoshi 1-guruhli bemorlarning y 54,6± 1,89 yoshni, 2-guruhli bemorlarning y 45,4± 1,44 yoshni tashkil etdi. Nazorat guruhi 35 yoshdan 54 yoshgacha bo'lgan 32 sog'lom kishidan iborat edi (o'rtacha yoshi 44,3 ± 0,95). Olingan natijalarning ishonchliligini baholash uchun ishlatiladigan statistik ishlov berish usullari Microsoft Excel va AtteStat dasturiy paketlari yordamida amalga oshirildi. Tahlil arifmetik o'rtacha (M), standart og'ish (σ), o'rtacha xato (m) ni aniqlashni o'z ichiga olgan. Natijalar. Bemorlarni o'rganish uchun tanlangan interferon holatini o'rganish 2-guruh bemorlarida inf-a-darajasining 1,67 baravar oshishini nazorat qiymatlariga qarshi ko'rsatdi, p<0,005. Va 1-guruh bemorlarida inf-a kontsentratsiyasi benchmark darajasida edi. INF-γ surunkali gepatitning klinik variantidan qat'i nazar, 1-guruh (XVGS) bemorlarida - 1,6 baravar, 2-guruh (XVGV) bemorlarida-1,67 marta -30,62± 2,62 PG/ml nazoratga qarshi ko'tarildi. Xulosa. Surunkali virusli gepatit albumin, umumiy xolesterin, IL-6 ning pasayishi fonida INF-γ ning ko'payishi bilan tavsiflanadi. Gepatit b bilan INF-a 1,5 baravar ko'payadi. Sitokinlarni o'rganish natijalari XVGS ning bakterial infeksiya bilan birikishi va/yoki XVGS fonida virusli-bakterial infeksiyaning kuchayishi holatini ko'rsatadi.
Kalit so'zlar:
Mualliflar haqida
Adabiyotlar ro'yxati
Akhmedova A.Kh., Inoyatova F.I., Valieva N.K. Marker profile of HBV infection in children with chronic hepatitis B and delayed puberty. Viral hepatitis - achievements and new perspectives: Collection of materials of the XII All-Russian scientific and practical conference with international participation. Moscow; 2019: 11-13.
Fazylov V.Kh. Etiological and pathogenetic aspects of diagnosis and treatment of viral hepatitis // Kazan Medical Journal. 2013. No. 6. P. 785-792.
Chronic viral hepatitis B and D in pregnant women: prevalence, course and outcomes (literature review). Akhmedova M.D., Tashpulatova Sh.A., Ikhtiyarova G.A., Karimova M.T. Journal of Infectology. 2021; 13(2): 29-37 DOI: 10.22625/2072-6732-2021-13-2-29-37
Onder G, Rezza G, Brusaferro S. Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy [published online ahead of print, 2020 Mar 23]. JAMA. 2020;10.1001/jama.2020.4683.
doi:10.1001/jama.2020.4683
Pei R.J. Control of hepatitis B virus replication by interferons and Toll-like receptor signaling pathways / R.J. Pei, X.W. Chen, M.J. Lu // World J. Gastroenterol. – 2014. –Vol. 20, № 33. – P. 11618–11629.
Sanders J.M., Monogue M.L., Jodlowsk T.Z, et al. Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19) A Review. JAMA. 2020. DOI: https://jamanetwork.com/ on 05/01/2020.
Torjesen I. Covid-19: One in 10 cases in England occurred in frontline health and social care staff. BMJ. 2020;370:m2717. Published 2020 Jul 7.
DOI:10.1136/bmj.m2717
Verity R, Okell LC, Dorigatti I, et al. Estimates of the severity of coronavirus disease 2019: a model-based analysis. Lancet Infect Dis.
;20(6):669-677. DOI:10.1016/S1473-3099(20)30243-7
Xu X., Barth R.F., Buja L.M. A call to action: the need for autopsies to determine the full extent of organ involvement associated with COVID-19 infections. CHEST. 2020. doi:10.1016/j.chest.2020.03.060.
Yamane D. Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation / D. Yamane, D.R. McGivern, E. Wauthier et al. // Nat. Med. – 2014. – Vol.20, № 8. – P. 927–935.
Qanday qilib iqtibos keltirish kerak
Это произведение доступно по лицензии Creative Commons «Attribution-NonCommercial-NoDerivatives» («Атрибуция — Некоммерческое использование — Без производных произведений») 4.0 Всемирная.