Bolalarda qalqonsimon bez va surunkali buyrak kasalligi
Annotatsiya
Kirish. Bolalarda surunkali buyrak kasalligi aniq metabolik, gormonal va yallig'lanish kasalliklari bilan birga keladi, ular orasida qalqonsimon bez holatining o'zgarishi muhim rol o'ynaydi. Buyrak faoliyati pasayishi bilan periferik qalqonsimon bez gormonlari metabolizmi buziladi, yod klirensi kamayadi, surunkali yallig'lanish kuchayadi va past T3 sindromiga xos bo'lgan laboratoriya profilini rivojlanish ehtimoli ortadi. Maqsad. Bolalarda surunkali buyrak kasalligida qalqonsimon bez disfunktsiyasi bo'yicha mavjud ma'lumotlarni umumlashtirish uchun ushbu bemor populyatsiyasida asosiy patogenetik mexanizmlarni, laboratoriya topilmalarini va qalqonsimon bez holati buzilishlarining klinik ahamiyatini o'rganing. Materiallar va usullar. Tadqiqot hikoya adabiyoti sharhi sifatida taqdim etilgan. Unda bolalarda surunkali buyrak kasalligi, buyrak funktsiyasi pasaygan qalqonsimon bez profili, past T3 sindromining patogenetik mexanizmlari va gormonal nomutanosiblikning klinik ahamiyati bo'yicha mavjud nashrlar tahlil qilinadi. Natijalar va muhokama. Surunkali buyrak kasalligiga chalingan bolalarda qalqonsimon bez disfunktsiyasi har doim ham birlamchi qalqonsimon bez patologiyasini aks ettirmaydi, chunki u ko'pincha uremik intoksikatsiya, deiodinaza faolligining buzilishi, yallig'lanishga qarshi sitokinlarning faollashishi bilan surunkali yallig'lanish, oqsil-energiya to'yib ovqatlanmaslik va metabolik kasalliklar fonida rivojlanadi. Gormonal nomutanosiblikning eng tipik varianti past T3 sindromidir, bu surunkali buyrak kasalligida tizimli metabolik moslashuvning belgisi deb hisoblanishi kerak. Bolalikda bu o'zgarishlar alohida klinik ahamiyatga ega, chunki ular o'sishning kechikishi, ovqatlanish holatining buzilishi, suyak metabolizmining o'zgarishi va organizmning moslashuvchan qobiliyatining pasayishi bilan bog'liq bo'lishi mumkin. Xulosa. Surunkali buyrak kasalligiga chalingan bolalarda qalqonsimon bez disfunktsiyasi tizimli kasalliklarning klinik jihatdan ahamiyatli namoyonidir va kuzatuv paytida, ayniqsa o'sishning kechikishi, to'yib ovqatlanmaslik belgilari va buyrak faoliyatining keskin pasayishi bo'lgan bemorlarda keng qamrovli baholashni talab qiladi.
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