STUDYING THE PHARMACOKINETICS OF GENTAMYCIN IN RATS WITH LYMPHOTROPIC PRETRACHEAL AND INTRAMUSCULAR INTRODUCTION

Abstract

The article is devoted to an experimental study of the pharmacokinetics of gentamicin in rats with lymphotropic pretracheal and intramuscular routes of administration. Data on the concentration of the antibiotic in the blood and tissues of the respiratory organs of rats in dynamics are given, it is shown that the method of lymphotropic pretracheal administration provides higher concentrations of the antibiotic in comparison with the intramuscular method. The high therapeutic efficiency of this method can be achieved due to the presence of connections between the lymphatic system, as well as organs and tissues. This circumstance allows you to deliver the drug to the affected organ directly. In addition, in the case of lymphotropic therapy in the focus, the optimal concentration of the drug is maintained for 24 hours. So there is no need for frequent administration of the drug (for example, with antibiotic therapy), you can reduce the course and daily doses of drugs. The drug, which is administered lymphotropically, is not able to have a toxic effect on the intestines, kidneys, liver, since only a tiny part of the drug enters the bloodstream.