CLINICAL AND FUNCTIONAL CHARACTERISTICS OF SICK CHILDREN WITH GLOMERULONEFRITIS WITH REDUCED THYROID FUNCTION

Abstract

Despite the obvious achievements in the study of this complex problem, a number of sections of nephrology are less studied. These diseases include glomerulonephritis and pyelonephritis. Successes in improving a systematic approach to providing medical care to children with nephrological pathology are determined primarily by in-depth knowledge of pathogenesis. The purpose of the study: to study the clinical and functional characteristics of sick children with glomerulonephritis with reduced thyroid function. Material and methods of research: The work is based on clinical observations, examination and treatment of 57 children with glomurulonephritis aged 3 to 17 years old, who were hospitalized in the neurological department of the children's clinic of the Andijan State Medical Institute during 2019-2022. The evaluation of thyroid function was carried out according to the study of the level of SBI (protein-bound iodine) by the biochemical method according to V.G. ) according to the calculation formulas, the level of TSH (thyroid-stimulating hormone) in the blood serum was studied. Results: acute and chronic glomerulonephritis with nephrotic variant in children with reduced thyroid activity was predominantly observed in school-age children, and was diagnosed much more often in boys. Analyzes characterizing the concentration of thyroid hormones in the blood serum of children with nephrotic syndrome indicate a reduced function of the thyroid gland: against the background of an increase in TSH, the levels of triiodothyronine (T3), total thyroxine (T4), protein-bound iodine (PBI), and also the coefficients of free and effective thyroxine were significantly lower. An inverse correlative, high correlation was found between the concentration of TSH and T4, SJ (respectively, r1 = -0.52, r2 = -061), which does not exclude the influence of an increased concentration of pituitary thyroid-stimulating hormone on the production of thyroid hormones. Conclusions: a characteristic feature of the clinical course of acute glomerulonephritis with a nephrotic component reduced thyroid function was the presence in most patients of a free-form and protracted course, a relatively high proportion of the transition of an acute process to a chronic one, and all patients had damage to kidney function, against the background of a violation of immunoregulatory mechanisms.