CLINICAL AND IMMUNOLOGICAL ASPECTS OF BRONCHIAL ASTHMA WITH ATOPIC DERMATITIS IN CHILDREN

Abstract

This article presents the results of a clinical and immunological examination of 68 children with allergic bronchial asthma and 22 children with atopic dermatitis. The purpose of the work is to determine the concentrations of IgA, IgM, IgG to identify clinical and immunological features in the blood serum of children with allergic asthma and AD and to identify clinical and immunological features in groups of these patients. Methods. At the allergy department of the VDOCH, 68 children with allergic asthma and 22 children with AD aged from 4 to 14 years (of which 53 boys and 37 girls) were examined. All children were examined clinically and laboratory (complete blood count, general urine test, biochemical blood test, nasal swab for eosinophils, stool test for helminth eggs, scraping for enterobiasis), and a carefully collected medical history. Results and conclusions: Taking into account the number of acute respiratory infections in the history, we identified significant differences in these groups of patients (p = 0.017). The concentrations of IgA, IgM, IgG in the blood serum of the examined patients were determined using an enzyme-linked immunosorbent assay (ELISA). We found that 33.8% of children with asthma and 36.4% of children with atopic dermatitis have low IgA levels. We also determined low IgG concentrations in more than half of the examined patients both in the group with bronchial asthma and in the group with atopic dermatitis (58.8% and 59.1%, respectively), which, in combination with low levels of other immunoglobulins, can be regarded as transient immunodeficiency in children.