THE ANALYSIS OF INDICATORS OF THE IMMUNE SYSTEM IN EARLY AGE CHILDREN WITH ACUTE PNEUMONIA WITH ACUTE HERPETIC STOMATITIS

Abstract

Infection caused by herpes simplex virus (HSV) is the most common among people (80-95% of the population are lifelong carriers of the virus). Conducted seroepidemiological studies have shown that by the age of 15, about 83% of children are infected with HSV, and at the age of 30 years and older, more than 90% of the population have antibodies to HSV of one type or another. Purpose of the study: analysis of clinical and immunological features of the course of severe pneumonia in young children against the background of acute herpetic stomatitis. Materials and methods: this study included 60 children with an established diagnosis of pneumonia. Group 1 consisted of 30 children with pneumonia of bacterial etiology without HSV, group 2 included 30 children with herpetic stomatitis. The control (comparison) group consisted of 22 practically healthy children of a similar age. Results: the clinical and immunological features of the course of severe pneumonia in young children against the background of acute herpetic stomatitis were determined. Conclusions: 1) An imbalance in the production of Th1/Th2 cytokines was established in children with stomatitis with pneumonia of various etiologies before treatment. 2) A significantly increased level of serum TNFα was revealed in all groups of children with stomatitis before treatment. 3) The study of IL-10 concentrations established differently directed indicators before treatment in the group of children without HSV and with HSV.