MODERN CHARACTERISTICS AND FACTORS AFFECTING ALPORT SYNDROME IN CHILDREN (literature review)
Abstract
In order to study the modern features and factors of influence of Alport syndrome in children, we analyzed data from literary sources of the last decade and the results of our scientific research. It has been established that in the last decade the incidence of Alport syndrome among children has been increasing, that is, contrary to information in the sources, the disease is diagnosed very often. Gene mutation plays a key role in the occurrence of pathology, and the frequency of autosomal dominant and autosomal recessive types of the disease differs fundamentally in the population. According to the etiological factors influencing the clinical course of Alport syndrome, the disease has regional characteristics. This appears in connection with extragenital and genital pathologies of the mother, marriage of close relatives, bad habits of parents, teratogenic effects of drugs on the fetus in the first three months of pregnancy, malformations of the urinary system in the child and secondary immune deficiency. Early detection of various stigmas of dysembryogenesis in children (dental diastema, Gothic palate, sandal-shaped space between the first and second fingers, hypertelorism of the eyes and nipples, syndactyly, polydactyly, bulging of the brow ridge, flat nose, defect of the auricle, hair growth to the forehead, clinodactyly, aplasia kidneys, renal hypoplasia, umbilical hernia) is important in the early diagnosis and assessment of the severity of Alport syndrome.
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