BOLALARDA ALPORT SINDROMINING ZAMONAVIY XUSUSIYATLARI VA TA’SIR QILUVCHI OMILLAR (adabiyotlar sharhi)

TO'LIQ MATN:

Abstrakt

Bolalarda Alport sindromining zamonaviy xususiyatlari va ta’sir qiluvchi omillarni o`rganish maqsadida oxirgi o`n yillikdagi adabiyot manbalari ma`lumotlari va ilmiy tadqiqotimiz natijalarini tahlil qildik. Aniqlandiki, so`nggi o`n  yillikda  bolalar orasida Alport sindromi ko`rsatkichi ortib bormoqda, ya’ni manbalardagi ma’lumotlardan farqli ravishda kasallik ko‘p tashxis qilinmoqda. Patologiya kelib chiqishida genlar mutatsiyasi asosiy o‘rin tutmoqda va kasallikning autosom-dominant va autosom-retsessiv turlari chastotasi axoli populyasiyalari bo`yicha tubdan farq qilmoqda. Alport sindromining klinik kechishiga ta’sir qiluvchi etiologik omillar bo`yicha kasallik o`z regional xususiyatlarini ko`rsatmoqda. Bu onaning ekstragenital va genital patologiyalari, yaqin qarindoshlik nikohi, ota-onaning zararli odatlari, homiladorlikning birinchi uch oyligida dori preparatlarining homilaga teratogen ta’siri, boladagi peshob tizimi a’zolari rivojlanish malfarmatsiyasi va ikkilamchi immun yetishmovchilik bilan bog‘liq tarzda namoyon bo`lmoqda. Bolalarda turli xil dizembriogenez stigmlarining (tishlar diastemasi, chuqurб gotik tanglay, I-II-panjalar orasi sandalsimon bo`shlig’i, ko‘zlar, ko`krak so`rg’ichi gipertelorizmi, sindaktiliya, polidaktiliya, bo‘rtgan qoshusti yoyi, yassi burun, quloq suprasi nuqsoni, sochni peshonagacha o`sishi, klinodaktiliya, buyrak aplaziyasi, gipoplaziyasi, chov, kindik churralari) erta aniqlanishi Alport sindromini erta tashxislash va ogirlik darajasini baholashda muxim o`rin tutmoqda.

Mualliflar haqida

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Qanday qilib iqtibos keltirish kerak

Rakhmanova Л. ., Karimdzhanov И., Arziqulov А. ., & Boltaboeva М. . (2024). BOLALARDA ALPORT SINDROMINING ZAMONAVIY XUSUSIYATLARI VA TA’SIR QILUVCHI OMILLAR (adabiyotlar sharhi). Xalqaro Ilmiy Pediatriya Jurnali, 3(4), 575–584. https://doi.org/10.56121/2181-2926-2024-3-4-575-584
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