COVID-19 DA MIOKARD SHIKASTLANISHINING MORFOLOGIK NAMOYON BO’LISHI
Abstrakt
Bugungi holatda COVID-19 patogenezi va morfogenezi yetarlicha o’rganilmagan, shuning uchun ushbu maqola COVID-19da miokard parenximatoz-stromal elementlarining shikastlanishini o’rganishga bag’ishlanadi. Tadqiqot materiali bo’lib 28 yoshdan 56 yoshgacha vafot etgan 26 bemorning COVID -19 da oshqozon devorlari miokardidan olingan kesmalar xizmat qiladi. Morfologik tadqiqot natijalari ko’rsatishicha, COVID-19da miokard interstitsial to’qimasining mukoid bo’kishi va shishishi gialuronan to’planishi, distrofiya, disgeneratsiya rivojlanishi hamda biriktiruvchi to’qima tuzilishi va tomirlar yallig’lanishi hisobiga yuz beradi. Miokard parenximasida kontraktli buzilish, kardiomiotsit sitoplazmalarining gomogen zichlashishi (jipslashishi), miofibrill ko’ndalang chizig’ining yo’qolishi, bazofiliyaning o’choqli rivojlanishi, kardiomiotsitlarning ShIK-ijobiy (musbat) metaplaziyasi,mushak tolalarining nekrobiozi va degeneratsiyasi; kardiomiotsitlar yadrosining parchalanishi va jipslashishi aniqlanadi. Shikastlangan kardiomiotsitlar dastlab yadro shakli va bo’yalishining o’zgarishi, sarkoplazma vakulizatsiyasida namoyon bo’ladi, so’ngra displaziya turida yadro giperxromaziyasi va yiriklashishi kuzatiladi, keyinchalik yadro haroratning sekin asta pastlab, bemorning sog’ayishi bilan havo rangda bo’yalishi hamda gomogenizatsiya, metaxromaziya aniqlanadi; keyinchalik metaxromaziya kardiomiotsit barcha sitoplazmasini egallaydi va hujayralar nobud bo’ladi.
Kalit so'zlar:
Mualliflar haqida
Adabiyotlar ro'yxati
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