QIZAMIQ KASALLIGIDA ICHKI A’ZOLAR MAKRO-MIKROSKOPIK HOLATI VA LIMFA TUGUNLARIDAGI PATOMORFOLOGIK O’ZGARISHLARNING O’ZIGA HOSLIGI
Abstrakt
Qizamiq kasalligi va uning asoratlaridan vafot etgan bolalar limfa tugunlaridagi asosiy morfofunktsional maydonlaridani patomorfologik oʼzgarishlar taxlil qilingan, bunda qizamiq kasalligi va uning asoratli formalaridagi oʼzgarishlarni morfologik maʼlumotlari qizamiq va uning asoratlari paytidagi immun tizimdagi oʼzgarishlarning oʼziga xosligi koʼrsatib oʼtilgan. Ishning maqsad va vazifalari: Qizamiqdan vafot etgan bemorlarning ichki a’zolari umumiy morfologik o’zgarishlari va limfa tuguni toʼqimalarida makro- va mikroskopik tekshiruvlarda yuzaga keladigan patomorfologik oʼzgarishlarni oʼziga xosligini oʼrganish. Materiallar va uslublar: 2024 yil qish va bahor oylarida qizamiqdan vafot etgan va Fargʼona viloyat patologoanatomiya byurosida tekshirilgan bemorlarning kasallik tarixi va austopsiya tekshiruvi maʼlumotlari tahlil qilingan. 2024 yil boshida dastlabki 3 oylikda 10453та bemor bola qayd qilingan, ularning aksariyati bir yoshgacha bolalar bo’lib, qolgan qismi 2-5 yoshli bolalar bo’lgan. Tadqiqot davomida vafot etgan bemor bolalar murdasi ichki a’zolari va limfa tugunlardan olingan autopsiya boʼlaklari formaldegid eritmasida (10% fosfat buferida tayyorlangan) 72 soat davomida fiksatsiyalangan va gematoksillin – eozin boʼyogʼida boʼyash orqali tekshirilgan. Natijalar va Xulosa: bolalarda qizamiq kasalligida oʼpkasida oʼchoqli pnevmoniya, buyrakda interstitsial pielonefrit, taloqda diffuz va oʼchoqli qon quyilishlar, jigarda distrofik oʼzgarishlar, yurakda oʼtkir destruktiv oʼzgarish, limfa tugunlarida qalinlashish, shish, follikulalar kamayishi, diffuz xolda nekroz oʼchoqlari, tugun kapsulasida va follikulyar boʼshliqlar orasida koʼp miqdorda leykotsitlar, limfotsitlar va fibrin bilan infiltratsiyalanganligi aniqlandi.
Kalit so'zlar:
Mualliflar haqida
Adabiyotlar ro'yxati
Measles: epidemiological features during the elimination period, modern possibilities of prevention, diagnosis and treatment. The importance of serological testing of population immunity. Methodical recommendations. Moscow, 2020. - P. 20-30.
Eremushkina Ya. M., Vdovina E. T., Kotiv S. I., Kuskova T. K. Algorithm for diagnosing measles in a complex epidemic situation. Analysis of clinical data. // Infectious diseases. 2015. No. 4. P. 76-82.
Mamaeva T. A., Zheleznova N. V., Naumova M. A. et al. Algorithm for laboratory confirmation and differential diagnosis of measles infection during the measles elimination period in the Russian Federation // Infection and immunity. 2015. No. 1. P. 55-62.Mina M. J., Kula T., Leng Y., Li M., de Vries R. D., Knip M., Siljander H., Rewers M., Choy D. F., Wilson M. S., Larman H. B., Nelson A. N., Griffin D. E., de Swart R. L., Elledge S. J. Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens. (англ.) // Science (New York, N.Y.). — 2019. — 1 November (vol. 366, no. 6465). — P. 599—606. — doi:10.1126/science.aay6485. — PMID 31672891.
Petrova V. N., Sawatsky B., Han A. X., Laksono B. M., Walz L., Parker E., Pieper K., Anderson C. A., de Vries R. D., Lanzavecchia A., Kellam P., von Messling V., de Swart R. L., Russell C. A. Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles. (англ.) // Science Immunology. — 2019. — 1 November (vol. 4, no. 41). — doi:10.1126/sciimmunol.aay6125. — PMID 31672862.
Mina M. J., Metcalf C. J., de Swart R. L., Osterhaus A. D., Grenfell B. T. Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality. (англ.) // Science (New York, N.Y.). — 2015. — 8 May (vol. 348, no. 6235). — P. 694—699. — doi:10.1126/science.aaa3662. — PMID 25954009
Yarmukhamedova N. A. et al. Functional changes in the cardiovascular system in patients with chronic forms of brucellosis." //Achievements of science and education. – 2020. – №. 4. – С. 58.
Tirkashev O. S. et al. Measles at the present stage //web of scientist: international scientific research journal. – 2022. – т. 3. – №. 5. – с. 177-185.
Saidov H.Sh., Tirkashev O.S. Study of the effect of measles vaccination on the epidemic process of the disease//Web of Scientist: International Scientific Research Journal. Vol 4 No.1 (2023): vos. C.560-565.
O’rolov J.B., Tirkashev O. S. Characteristics of the clinical course of salmonellosis disease in children of early age//Web of Scientist: International Scientific Research Journal. Vol 4 No.1 (2023): vos. C.573-577.
Ne’matov H.A., Tirkashev O. S. Specific clinical and epidemiological features of scarlet fever//Web of Scientist: International Scientific Research Journal. Vol 4 No.1 (2023): vos. C.578-584
Qanday qilib iqtibos keltirish kerak
Это произведение доступно по лицензии Creative Commons «Attribution-NonCommercial-NoDerivatives» («Атрибуция — Некоммерческое использование — Без производных произведений») 4.0 Всемирная.