URIC ACID INDICATORS IN BLOOD IN CHILDREN WITH VARIOUS TYPES OF OBESITY

Abstract

The original article presents the results of a study of the state of uric acid metabolism in children with different types of distribution of adipose tissue in exogenous-constitutional obesity, with the determination of the role of hyperuricemia in the development of complications in obesity. The results of the study are recommended for widespread implementation in the practice of general practitioners and pediatricians. Purpose of the study: to assess the diagnostic significance of increased uric acid levels in children with different types of obesity. Materials and methods: 211 children with primary exogenous constitutional obesity aged 7 to 18 years, as well as 104 children with normal body weight were examined. A set of anthropometric, clinical, biochemical, and enzyme immunoassay studies was conducted. Results: it was determined that the frequency of hyperuricemia increased accordingly from the group of children with abdominal obesity to children with normal body weight, the frequency of hyperuricemia in children with abdominal obesity was 2.4 times higher than in children with a uniform type of obesity, and 19.5 times higher than in the control group. and 19.563 times higher than in the control group. When determining the level of UA depending on gender, its higher content was found in boys, which was reliably high in relation to girls only in children with a uniform type of obesity, while in children with an abdominal type of distribution of adipose tissue, the level of uric acid in girls approached the level of boys. An increase in uric acid levels was revealed depending on the degree of obesity. Conclusion: The revealed difference between the two groups with different types of obesity characterized the abdominal type as provoking the development of GU in children. The absence of gender differences characterizes the severity of purine metabolism disorders regardless of gender in abdominal obesity. An increase in uric acid levels depending on the degree of obesity characterizes the contribution of uric acid metabolism pathology to the development of complications against the background of severe obesity, forming metabolic syndrome.