OBESITY AND NON-ALCOHOLIC FATTY LIVER HEPATOSIS PERSONALISED APPROACH TO CORRECTION
Abstract
The review article describes the main causes of non-alcoholic fatty liver disease, pathogenesis, clinical picture, diagnostics and treatment. The article presents the relationship between the development of non-alcoholic fatty liver disease and obesity, especially its abdominal type and metabolic syndrome. Overweight and obesity in children and adults worldwide, which have reached pandemic proportions, are risk factors for many chronic non-communicable diseases, including type 2 diabetes mellitus, cardiometabolic diseases, musculoskeletal pathology, cholelithiasis, obstructive sleep apnea syndrome, reproductive dysfunction, and neoplasms. The gastrointestinal tract, including the hepatobiliary system, plays a key role in the pathogenesis of metabolic disorders, and they themselves become target organs as a result of insulin resistance and dyslipidemia against the background of obesity, which is accompanied by pathological accumulation of fat droplets (including triglycerides) in hepatocytes, not associated with alcohol consumption, and the development of non-alcoholic fatty liver disease.
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