CURRENT STRATEGIES OF ANTIBIOTIC THERAPY OF ACUTE RESPIRATORY INFECTIONS IN PEDIATRIC PRACTICE
Abstract
Resume. Acute respiratory pathology remains the leading cause of morbidity among the child population of the country. This review article highlights modern approaches to antibacterial therapy of infectious diseases of the respiratory tract in pediatric patients. Material and method. Analyz provedyon na osnobe obzora tekushchikh publication v bazax PubMed, Scopus i eLibrary za poslednie 10 let.Based on the analysis of modern scientific data, key factors influencing the choice of antibacterial drugs for respiratory infections are identified. Conclusion.The main reasons for the unjustified prescription of antibiotics in pediatrics include overdiagnosis by doctors, the desire to meet parental expectations, and the desire to accelerate the achievement of clinical improvement. Also, factors worsening the prognosis with irrational antibiotic therapy in pediatrics are identified.
About the Authors
List of references
Alimova N.A., Muratov A.A., Kutuyev Zh.Ak. Disadvantages of preventive examinations in the context of respiratory diseases in children // Biology and integrative medicine. 2025. - Vol. 1-№72-P. 596-616. doi:10.24412/cl-34438-2025-596-616
Blokhin B.M., Steshin V.Yu., Gordienko G.I., Bessonov E.E., Erenko O.V., et al. Pharmacoepidemiological study of the treatment of frequently ill children: analysis of preferences of primary care pediatricians in the choice of therapy. // Childhood infections. 2025. - Vol.24 - № 1- P.26-32. doi:10.22627/2072-8107-2025-24-1-26-32 DOI: https://doi.org/10.22627/2072-8107-2025-24-1-26-32
Kramarev S.A., Grechukha E.O. Aspects of treatment of lower respiratory tract infections from the point of view of clinical guidelines of different countries (bronchiolitis, bronchitis, community-acquired pneumonia) // AI. 2019.- No. 4. - P. 181-188.
Nasirova GR, Turdieva Sh.T. Features of immunity in children with acute tonsillitis during treatment with bacteriophages//Children's Medicine of the North-West. 2020.- No. 8(1). -P. 248-2495.
Nasirova GR, Turdieva Sh.T. Modern aspects of the inhalation method of therapy for bronchopulmonary diseases in children//Problems of biology and medicine), Samarkand, 2024. - No. 2 (152) - P. 344-350.
Ovsyannikov D. Yu., Tsygankov A. E., Boytsova E. V., Gitinov Sh. A., Karpenko M. A., Sigova Yu. A., Ledneva S. A., Maygadzhieva M. T. ""Riddles" of acute bronchiolitis"// Neonatology: News. Opinions. Training, 2025. - No. 1 (47) - P. 41-51. doi: 10.33029/2308-2402-2025-13-1-41-51 DOI: https://doi.org/10.33029/2308-2402-2025-13-1-41-51
Simonova A. Yu. The use of clarithromycin in the treatment of acute respiratory diseases in children // VSP. 2022. - No. 1. - P. 152-157. DOI: https://doi.org/10.15690/vsp.v11i1.148
Ahmed MN, Muyot MM, Begum S, Smith P, Little C, Windemuller FJ. Antibiotic prescription pattern for viral respiratory illness in emergency room and ambulatory care settings. Clin Pediatr (Phila) 2020; 49:542–547. DOI: https://doi.org/10.1177/0009922809357786
Akkerman AE, Kuyvenhoven MM, van der Wouden JC, Verheij TJM. Determinants of antibiotic overprescribing in respiratory tract infections in general practice. J Antimicrob Chemother. 2021;56:930–936. DOI: https://doi.org/10.1093/jac/dki283
Aspinall SL, Good CB, Metlay JP, Mor MK, Fine MJ. Antibiotic prescribing for presumed nonbacterial acute respiratory tract infections. Am J Emerg Med. 2009; 27:544–551. doi:10.1016/j.ajem.2008.04.015. DOI: https://doi.org/10.1016/j.ajem.2008.04.015
Bennett JE, Dolin R, Blaser MJ. Mandell, Douglas, and Bennett's principles and practice of infectious diseases. Saunders, Philadelphia, PA. 2023: 138.
Brown DW, Taylor R, Rogers A, Weiser R, Kelley M. Antibiotic prescriptions associated with outpatient visits for acute upper respiratory tract infections among adult Medicaid recipients in North Carolina. N C Med J 2023: 64:148–156. DOI: https://doi.org/10.18043/ncm.64.4.148
Butler CC, Kelly MJ, Hood K, Schaberg T, Melbye H, et al. Antibiotic prescribing for discoloured sputum in acute cough/lower respiratory tract infection. Eur Resp J 2021;38:119–125. DOI: https://doi.org/10.1183/09031936.00133910
Calbo E, Alvarez-Rocha L, Gudiol F, Pasquau J. A review of the factors influencing antimicrobial prescribing. Enferm Infecc Microbiol Clin 2013;31(Suppl 4):S12–S15. DOI: https://doi.org/10.1016/S0213-005X(13)70127-7
Cayley WE. Beta2 agonists for acute cough or a clinical diagnosis of acute bronchitis. Am Fam Physician. 2017;95:551
Dosh SA, Hickner JM, Mainous AG, Ebell MH. Predictors of antibiotic prescribing for nonspecific upper respiratory infections, acute bronchitis, and acute sinusitis. A UPRNet study. Upper Peninsula Research Network. J Fam Pract. 2020;58:377–384.
Gaur AH, Hare ME, Shorr RI. Provider and practice characteristics associated with antibiotic use in children with presumed viral respiratory tract infections. Pediatrics 2021;115:635–641. DOI: https://doi.org/10.1542/peds.2004-0670
Lopez-Vazquez P, Vazquez-Lago JM, Figueiras A. Misprescription of antibiotics in primary care: a critical systematic review of their determinants. J Eval Clin Pract 2021;22:373–384.
Lyu YR, Yang WK, Park SJ, et al. Efficacy and safety of GHX02 in the treatment of acute bronchitis: protocol of a phase II, double-blind, randomized placebo-controlled trial. BMJ Open. 2018;8(5):e019897. doi:10.1136/bmjopen-2017-019897 DOI: https://doi.org/10.1136/bmjopen-2017-019897
McKay R, Mah A, Law MR, McGrail K, Patrick DM. Systematic Review of Factors Associated with Antibiotic Prescribing for Respiratory Tract Infections. Antimicrob Agents Chemother. 2016;60(7):4106–4118. doi:10.1128/AAC.00209-16 DOI: https://doi.org/10.1128/AAC.00209-16
Moro ML, Marchi M, Gagliotti C, Di Mario S, Resi D, Progetto Bambini a Antibiotici. Why do pediatricians prescribe antibiotics? Results of an Italian regional project. BMC Pediatr. 2019; 9:69. DOI: https://doi.org/10.1186/1471-2431-9-69
Turdieva ST, Ganieva DK, Nasirova GR. Influence of inhaled bacteriophage therapy on oral mucosal immunity in children with acute tonsillitis. Russian Journal of Infection and Immunity, 2023;13(5): 939-946. DOI: https://doi.org/10.15789/2220-7619-IOI-2081
Turdieva Sh.T., Nasirova G.R. Oral Microbiota in Children with Acute Tonsis llitis. Biomedical and Biotechnology Research Journal (BBRJ), Jul–Sep 2021; 5(3): 272-275, doi: 10.4103/bbrj.bbrj_84_21. DOI: https://doi.org/10.4103/bbrj.bbrj_84_21
Weber S, Schlaeppi C, Barbey F, Buettcher M, Deubzer B, Duppenthaler A, Jaboyedoff M, Kahlert C, Kottanattu L, Relly C, Wagner N, Zimmermann P, Heininger U. Clinical Characteristics and Management of Children and Adolescents Hospitalized With Pyomyositis. Pediatr Infect Dis J 2024 Sep 1;43(9):831-840. doi: 10.1097/INF.0000000000004382. DOI: https://doi.org/10.1097/INF.0000000000004382
How to Cite

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.