ASSESSMENT OF IMMUNE SYSTEM PARAMETERS IN CHILDREN WITH GASTRODUODENAL PATHOLOGY

Abstract

Relevance: In Children, early immunity to X pylori infection may serve as a model for pathological response and learning. In the conditions of the Republic of Uzbekistan, such studies have not been carried out, however, weight gain, a tendency to rejuvenation and a high incidence of complications dictate the need to study this issue. Patients and methods. The aim of the study was to include children with gastroduodenal pathology associated and not associated with CP from the entire cohort of examined children. Materials and methods of the study: According to the tasks set, out of the entire cohort of examined children, children with HP associated and non-associated gastroduodenal pathology were included in the study. We conducted a study of immune response mediators using IL-1β and TNFα as an example in 165 sick children and, for comparison, in 50 practically healthy children of the same age who made up the control group. Based on the above, groups of children with H.pilori "+" and H.pilori "-" pathology of the gastroduodenal zone were divided into 2 subgroups depending on age. Results: The levels of IL-1B in the control group of children aged 7-14 years were 21.6±0.86 pg/ml compared with 24.2±0.72 pg/ml in children aged 15-18 years. In children aged 15-18 years, 27.4±0.76 pg/ml.