SUSAYGAN QALQONSIMON BEZ FUNKSIYASIDA GLOMERULONEFRITLI KASAL BOLALARNING KLINIK-FUNKTSIONAL XUSUSIYATLARI.
Abstrakt
Ushbu murakkab muammoni o'rganishda aniq yutuqlarga qaramay, nefrologiyaning bir qator bo'limlari kam o'rganilgan. Ushbu kasalliklarga glomerulonefrit va pielonefrit kiradi. Nefrologik patologiyasi bo'lgan bolalarga tibbiy yordam ko'rsatishda tizimli yondashuvni takomillashtirishdagi muvaffaqiyatlar, birinchi navbatda, patogenezni chuqur bilish bilan belgilanadi. Tadqiqot maqsadi: qalqonsimon bez funksiyasi susaygan glomerulonefritli kasal bolalarning klinik va funksional xususiyatlarini o'rganish. Tadqiqot materiali va usullari: Ish 2019-2022 yillar davomida Andijon davlat tibbiyot instituti bolalar poliklinikasi nevrologiya bo‘limiga yotqizilgan 3 yoshdan 17 yoshgacha bo‘lgan 57 nafar glomurulonefrit bilan og‘rigan bolalarni klinik kuzatish, tekshirish va davolashga asoslangan. . Qalqonsimon bez funktsiyasini baholash V.G.ga ko'ra biokimyoviy usulda SBI (oqsil bilan bog'langan yod) darajasini, hisoblash formulalari bo'yicha, qondagi TSH (qalqonsimon bezni ogohlantiruvchi gormon) darajasini o'rganish asosida amalga oshirildi. sarum o'rganildi. Natijalar: Qalqonsimon bez faoliyati susaygan bolalarda nefrotik variant bilan o'tkir va surunkali glomerulonefrit asosan maktab yoshidagi bolalarda kuzatilgan va o'g'il bolalarda ko'proq tashxis qo'yilgan. Nefrotik sindromli bolalarning qon zardobida qalqonsimon gormonlar kontsentratsiyasini tavsiflovchi tahlillar qalqonsimon bez funktsiyasining pasayishini ko'rsatadi: TSH ortishi fonida triiodotironin (T3), umumiy tiroksin (T4), protein- bog'langan yod (PBI), shuningdek, erkin va samarali tiroksin koeffitsientlari sezilarli darajada past edi. TSH va T4, SJ (mos ravishda r1 = -0,52, r2 = -061) kontsentratsiyasi o'rtasida teskari korrelyatsion, yuqori korrelyatsiya aniqlandi, bu gipofiz bezining qalqonsimon bezni ogohlantiruvchi gormoni kontsentratsiyasining ortishi ta'sirini istisno qilmaydi. Qalqonsimon bez gormonlari.. Xulosa: nefrotik komponentli o'tkir glomerulonefritning klinik kechishining xarakterli xususiyati qalqonsimon bez funktsiyasining pasayishi bo'lgan bemorlarning ko'pchiligida erkin shakldagi va uzoq davom etadigan kursning mavjudligi, o'tkir jarayonning o'tkir jarayonga o'tishning nisbatan yuqori nisbati edi. surunkali bo'lib, barcha bemorlarda immunoregulyatsion mexanizmlarning buzilishi fonida buyraklar faoliyati buzilgan.
Kalit so'zlar:
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