O’RS BILAN KASALLANGAN OIV INFEKTSIYALI BOLALARDA IMMUN STATUS TAVSIFI
Abstrakt
Immunitet holati O’RS bilan kasallangan 35 nafar OIV infektsiyali bolalarda o'rganildi. Nazorat guruhini 14 nafar sog'lom bolalar tashkil etdi. OIV bilan kasallangan O’RS bilan kasallangan bemorlarda immunitetning chuqur buzilishlari, ayniqsa immunitetning T-bo'g'inlari va uning subpopulyatsiyalari, shuningdek, immunitetning gumoral bog'lanishining buzilishi, yallig'lanishga qarshi sitokinning bostirilishi aniqlangan. IL-10 va yallig'lanishga qarshi IFN-g ning ko'payishi kuzatildi. O'tkazilgan davolanishning ta'siri ostida bemorlarda immunitet holatida aniq o'zgarishlar aniqlanmadi. Biz faqat IL-10 tarkibidagi ijobiy o'zgarishlarni va davolash dinamikasida IFN-g ning parallel pasayishini aytishimiz mumkin. Asosiy guruhda OIV bilan kasallangan 25 nafar ARS bilan kasallangan bemorlar, nazorat guruhida esa xuddi shu yoshdagi 14 nafar amalda sog'lom, OIV va OIV bilan kasallangan bolalar bor edi. OIV infeksiyasiga chalingan 35 nafar bolaning barchasi Buxoro viloyati OITSga qarshi kurash markazida ro‘yxatga olingan. Bemorlarga shifoxona sharoitida antiretrovirus terapiyasi, antibakterial, yallig'lanishga qarshi va mahalliy terapiya o'tkazildi.
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Adabiyotlar ro'yxati
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