BOLALARDA INFILTRATIV-YIRINGLI LARINGITNI ANTIBAKTERIAL DAVOLASH: MUAMMO VA ISTIQBOLLAR
Abstrakt
Bolalarda kuzatiladigan infiltrativ-yiringli laringit yuqori nafas yo‘llarining klinik jihatdan eng ahamiyatli va potensial xavfli kasalliklaridan biri bo‘lib, u keskin darajadagi hiqildoq stenozi va yiringli-yallig‘lanish asoratlarining yuqori xavfi bilan tavsiflanadi. Kasallik etiologiyasining o‘zgarib borishi hamda antibiotiklarga chidamlilikning ortib borayotgani sharoitida optimal antibakterial terapiyani tanlash murakkab va bahsli masala bo‘lib qolmoqda. Ushbu sharhda bolalarda infiltrativ-yiringli laringitning etiologiyasi, patogenezi va klinik xususiyatlari bo‘yicha zamonaviy ilmiy ma’lumotlar tizimlashtirilgan, shuningdek, antibakterial preparatlarni oqilona qo‘llashning asosiy tamoyillari yoritilgan. Alohida e’tibor turli guruh antibiotiklaridan foydalanishning patogenetik asoslariga, ularning farmakokinetik xususiyatlariga hamda xos patogenlarga nisbatan faollik spektriga qaratilgan. Mikrob agentlarining ortib borayotgan rezistentligi, klinik amaliyotda antibiotiklarni noto‘g‘ri buyurish holatlarining davom etishi va bemorlarning yetarli darajada muvofiq bo‘lmasligi bilan bog‘liq muammolar tahlil qilingan. Peditriya amaliyotida antibakterial terapiyaning xavfsizligi, jumladan, nojo‘ya ta’sirlar xavfi, yoshga oid cheklovlar va mumkin bo‘lgan asoratlarni monitoring qilish zarurati alohida ko‘rib chiqilgan. Maqolada shuningdek kombinatsiyalangan davolashning zamonaviy yondashuvlari, jumladan, tizimli glyukokortikosteroidlar, yallig‘lanishga qarshi preparatlar, ingalyatsion terapiya hamda murakkab holatlarda jarrohlik aralashuvlarining o‘rni ko‘rib chiqiladi. Antibakterial terapiyani takomillashtirishning asosiy yo‘nalishlari – individual yondashuv asosidagi davolash sxemalarini ishlab chiqish va antibiotikrezistentlikni nazorat qilish dasturlarini kengaytirish – istiqbolli yo‘nalishlar sifatida belgilangan.
Kalit so'zlar:
Mualliflar haqida
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